Double-Screw Osteosynthesis in an Unstable Scaphoid Fracture Model: A Biomechanical Comparison of Two Screw Configurations

CONCLUSIONS: There are no significant biomechanical differences between the sagittal or coronal aligned double headless compression screws in a scaphoid fracture model with bone loss.CLINICAL RELEVANCE: In cases where double-screw fixation of the scaphoid is being considered, the placement of double screws can be at the discretion of the surgeon, and can be dictated by ease of access, surgical preference, and fracture orientation.PMID:34690014 | DOI:10.1016/j.jhsa.2021.08.019
Source: Hand Surgery - Category: Surgery Authors: Source Type: research

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Deep brain stimulation (DBS) serves as a treatment for neurological and psychiatric disorders, such as Parkinson's disease (PD), essential tremor, dystonia, Tourette Syndrome (GTS), Huntington's disease, and obsessive-compulsive disorder (OCD). There is broad experience with the short-term effects of DBS in individual diseases and their signs/symptoms. However, even in acute treatment and for the same disorder or a given disorder, a prediction of effect is not perfect. Even further, the factors that influence the long-term effect of DBS and its withdrawal are hardly characterized. In this work, we aim to shed light on an i...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Protein Pept Lett. 2021 Nov 24. doi: 10.2174/0929866528666211125114421. Online ahead of print.ABSTRACTThe failure of protein to correctly fold into its functional and unique three dimensional form leads to misfolded or partially folded protein. When these rogue proteins and polypeptides escape the quality control mechanism within the body, they result in aberrant aggregation of proteins into characteristic amyloid fibrils. This is the main cause for the number of neurodegenerative diseases, including Alzheimer's disease, Parkinson's and Huntington's diseases. This review aims to summarise the underlying mechanisms of prote...
Source: Protein and Peptide Letters - Category: Biochemistry Authors: Source Type: research
Curr Neuropharmacol. 2021 Jul 12. doi: 10.2174/1570159X19666210712152532. Online ahead of print.ABSTRACTNowadays, neurodegenerative diseases (NDs), such as Parkinson's disease (PD), Alzheimer's disease (AD), Huntington's disease (HD), and amyotrophic lateral sclerosis (ALS), represent a great challenge for different scientific fields, such as neuropharmacology, medicinal chemistry, molecular biology, and medicine, once all these pathologies remain incurable, with high socio-economic impacts and high costs for governmental health services. Due to their severity and multifactorial pathophysiological complexity, the available...
Source: Current Neuropharmacology - Category: Drugs & Pharmacology Authors: Source Type: research
Protein Pept Lett. 2021 Nov 24. doi: 10.2174/0929866528666211125114421. Online ahead of print.ABSTRACTThe failure of protein to correctly fold into its functional and unique three dimensional form leads to misfolded or partially folded protein. When these rogue proteins and polypeptides escape the quality control mechanism within the body, they result in aberrant aggregation of proteins into characteristic amyloid fibrils. This is the main cause for the number of neurodegenerative diseases, including Alzheimer's disease, Parkinson's and Huntington's diseases. This review aims to summarise the underlying mechanisms of prote...
Source: Protein and Peptide Letters - Category: Biochemistry Authors: Source Type: research
Curr Neuropharmacol. 2021 Jul 12. doi: 10.2174/1570159X19666210712152532. Online ahead of print.ABSTRACTNowadays, neurodegenerative diseases (NDs), such as Parkinson's disease (PD), Alzheimer's disease (AD), Huntington's disease (HD), and amyotrophic lateral sclerosis (ALS), represent a great challenge for different scientific fields, such as neuropharmacology, medicinal chemistry, molecular biology, and medicine, once all these pathologies remain incurable, with high socio-economic impacts and high costs for governmental health services. Due to their severity and multifactorial pathophysiological complexity, the available...
Source: Current Neuropharmacology - Category: Drugs & Pharmacology Authors: Source Type: research
Protein Pept Lett. 2021 Nov 24. doi: 10.2174/0929866528666211125114421. Online ahead of print.ABSTRACTThe failure of protein to correctly fold into its functional and unique three dimensional form leads to misfolded or partially folded protein. When these rogue proteins and polypeptides escape the quality control mechanism within the body, they result in aberrant aggregation of proteins into characteristic amyloid fibrils. This is the main cause for the number of neurodegenerative diseases, including Alzheimer's disease, Parkinson's and Huntington's diseases. This review aims to summarise the underlying mechanisms of prote...
Source: Protein and Peptide Letters - Category: Biochemistry Authors: Source Type: research
CONCLUSION: Collectively, our results suggested that hESCs transplantation can be a potential treatment for motor dysfunction of Huntington's disease.PMID:34809707 | DOI:10.1186/s13287-021-02653-7
Source: Cell Research - Category: Cytology Authors: Source Type: research
Exp Neurol. 2021 Nov 20:113929. doi: 10.1016/j.expneurol.2021.113929. Online ahead of print.ABSTRACTObstructive sleep apnea-hypopnea syndrome (OSAHS) is widely known for its multiple systems damage, especially neurocognitive deficits in children. Since their discovery, adenosine A2A receptors (A2ARs) have been considered as key elements in signaling pathways mediating neurodegenerative diseases such as Huntington's and Alzheimer's, as well as cognitive function regulation. Herein, we investigated A2AR role in cognitive impairment induced by chronic intermittent hypoxia (CIH). Mice were exposed to CIH 7 h every day for 4 we...
Source: Experimental Neurology - Category: Neurology Authors: Source Type: research
CONCLUSION: The deficiency of vitamins in the body causes various neurological disorders like Alzheimer's disease, Parkinson's disease, Huntington's disease, and depression. We have discussed the role of vitamins in neurological disorders and the normal human body. Depression is linked to a deficiency of vitamin-C and vitamin B. In the case of Alzheimer's disease, there is a lack of vitamin-B1, B12, and vitamin-A, which results in Aβ-plaques. Similarly, in Parkinson's disease, vitamin-D deficiency leads to a decrease in the level of dopamine, and imbalance in vitamin D leads to accumulation of synuclein. In MS, Vitami...
Source: CNS and Neurological Disorders Drug Targets - Category: Drugs & Pharmacology Authors: Source Type: research
In conclusion, our work provides new insight into the underlying mechanisms of the high incidence of diabetes and abnormal glucose homeostasis in HD.
Source: Journal of Molecular Neuroscience - Category: Neuroscience Source Type: research
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