Whole-cell pertussis vaccine in early infancy for the prevention of allergy in children

CONCLUSIONS: There is very low-certainty evidence that a first dose of wP given early in infancy, compared to a first dose of aP, affects the risk of atopic diseases in children. The incidence of all-cause SAEs in wP and aP vaccinees was low, and no cases of encephalopathy were reported. The certainty of the evidence was judged as moderate for all-cause SAEs, and low for encephalopathy. Future studies should use sensitive and specific endpoints of clinical relevance, and should be conducted in settings with high prevalence of IgE-mediated food allergy. Safety endpoints should prioritise common vaccine reactions, parental acceptability, SAEs and their potential relatedness to the dose administered.PMID:34693993 | DOI:10.1002/14651858.CD013682.pub2

Source: Cochrane Database of Systematic Reviews - October 25, 2021 Category: General Medicine Authors: Gladymar Perez Chacon Jessica Ramsay Christopher G Brennan-Jones Marie J Estcourt Peter Richmond Patrick Holt Tom Snelling Source Type: research