Cancers, Vol. 13, Pages 5360: Molecular Imaging in Primary Staging of Prostate Cancer Patients: Current Aspects and Future Trends

Cancers, Vol. 13, Pages 5360: Molecular Imaging in Primary Staging of Prostate Cancer Patients: Current Aspects and Future Trends Cancers doi: 10.3390/cancers13215360 Authors: Reyhaneh Manafi-Farid Shaghayegh Ranjbar Zahra Jamshidi Araghi Julia Pilz Gregor Schweighofer-Zwink Christian Pirich Mohsen Beheshti Accurate primary staging is the cornerstone in all malignancies. Different morphological imaging modalities are employed in the evaluation of prostate cancer (PCa). Regardless of all developments in imaging, invasive histopathologic evaluation is still the standard method for the detection and staging of the primary PCa. Magnetic resonance imaging (MRI) and computed tomography (CT) play crucial roles; however, functional imaging provides additional valuable information, and it is gaining ever-growing acceptance in the management of PCa. Targeted imaging with different radiotracers has remarkably evolved in the past two decades. [111In]In-capromab pendetide scintigraphy was a new approach in the management of PCa. Afterwards, positron emission tomography (PET) tracers such as [11C/18F]choline and [11C]acetate were developed. Nevertheless, none found a role in the primary staging. By introduction of the highly sensitive small molecule prostate-specific membrane antigen (PSMA) PET/CT, as well as recent developments in MRI and hybrid PET/MRI systems, non-invasive staging of PCa is being contemplated. Several studies investigated the role of these sophistica...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research