Progress in the Management of Pancreatic Neuroendocrine Tumors

Annu Rev Med. 2021 Oct 20. doi: 10.1146/annurev-med-042320-011248. Online ahead of print.ABSTRACTPancreatic neuroendocrine tumors (PNETs) are a heterogeneous and orphan group of neoplasms that vary in their histology, clinical features, prognosis, and management. The treatment of PNETs is highly dependent on the stage at presentation, tumor grade and differentiation, presence of symptoms from hormonal overproduction or from local growth, tumor burden, and rate of progression. The US Food and Drug Administration has recently approved many novel treatments, which have altered decision making and positively impacted the care and prognosis of these patients. In this review, we focus on the significant progress made in the management of PNETs over the past decade, as well as the active areas of research. Expected final online publication date for the Annual Review of Medicine, Volume 73 is January 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.PMID:34669433 | DOI:10.1146/annurev-med-042320-011248
Source: Annual Review of Medicine - Category: General Medicine Authors: Source Type: research