Impact of residual subretinal fluid volumes on treatment outcomes in a subretinal fluid–tolerant treat-and-extend regimen

Purpose: To investigate associations between residual subretinal fluid (rSRF) volumes, quantified using artificial intelligence and treatment outcomes in a subretinal fluid (SRF)–tolerant treat-and-extend (T&E) regimen in neovascular age-related macular degeneration. Methods: Patients enrolled in the prospective, multicenter FLUID study randomized in an SRF-tolerant T&E regimen were examined by spectral-domain optical coherence tomography and tested for best-corrected visual acuity (BCVA). Intraretinal fluid and SRF volumes were quantified using artificial intelligence tools. In total, 375 visits of 98 patients were divided into subgroups: extended intervals despite rSRF and extended intervals without fluid. Associations between BCVA change, SRF volume, subgroups, and treatment intervals were estimated using linear mixed models. Results: In extended intervals despite rSRF, increased SRF was associated with reduced BCVA at the next visit in the central 1 mm (−0.138 letters per nL; P = 0.014) and 6 mm (−0.024 letters per nL; P = 0.049). A negative association between increased interval and BCVA change was found for rSRF in 1 mm and 6 mm (−0.250 and −0.233 letter per week interval, respectively; both P
Source: RETINA - Category: Opthalmology Tags: Original Study Source Type: research