Malaria parasite liver stages

Malaria, caused by Plasmodium (P.) parasite species, poses a significant global health burden. There were 229 million malaria cases reported in 2019 and 95% of the 409,000 global malaria-caused fatalities occurred in sub-Saharan Africa (World Malaria Report 2020). Infection of the human host begins with a Plasmodium-infected mosquito bite that deposits sporozoites in the skin. Sporozoites enter blood vessels, are transported to the liver and invade hepatocytes. Within a hepatocyte, each sporozoite transforms into a liver stage (LS), which differentiates into tens of thousands of exo-erythrocytic merozoites.
Source: Journal of Hepatology - Category: Gastroenterology Authors: Tags: Hepatology Snapshot Source Type: research