Association of four genetic variants with colorectal cancer in Kazakhstan population

Oncotarget. 2021 Oct 12;12(21):2215-2222. doi: 10.18632/oncotarget.28070. eCollection 2021 Oct 12.ABSTRACTThe study was conducted to search for polymorphisms located in the 10th chromosome associated with colorectal adenocarcinoma in representatives of the Kazakhstan population. Study was performed with 282 colorectal cancer (CRC) patients and 159 controls. Genotyping of SNPs was performed by QuantStudio 12K Flex PCR. For four significant SNPs inheritance model analysis was performed. Increasing risk of CRC was noted for rs10795668 in log-additive model (OR = 1.45, 95% CI: 1.05-1.99, p = 0.023); for rs1035209 in log-additive model (OR = 1.79, 95% CI: 1.18-2.72, p = 0.003); for rs11190164 in log-additive model (OR = 1.67, 95% CI: 1.17-2.38, p = 0.004). Decreasing risk of CRC was noted for rs10506868 in log-additive model (OR = 0.56, 95% CI: 0.37-0.85, p = 0.006). We detected SNPs that are associated with CRC risk in the Kazakhstan population.PMID:34676053 | PMC:PMC8522836 | DOI:10.18632/oncotarget.28070

Source: Oncotarget - October 22, 2021 Category: Cancer & Oncology Authors: Yevgeniya Kolesnikova Dmitriy Babenko Irina Kadyrova Svetlana Kolesnichenko Lyudmila Akhmaltdinova Ilya Korshukov Naylya Kabildina Valentina Sirota Vera Zhumaliyeva Dana Taizhanova Dmitriy Vazenmiller Anar Turmukhambetova Source Type: research