Association of VEGFA promoter polymorphisms rs699947 and rs35569394 with diabetic retinopathy among North-Central Indian subjects: a case-control study

CONCLUSIONS: Results of our study support the hypothesis that D-allele and DD-genotype of rs35569394 have deleterious effect on the progression of DR. C-allele had skewed frequency towards DR III subjects owing to strong linkage disequilibrium between C-allele (rs699947) and D-allele (rs35569394).PMID:34693874 | DOI:10.1080/13816810.2021.1992786
Source: Ophthalmic Genetics - Category: Opthalmology Authors: Source Type: research

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CONCLUSIONS: Results of our study support the hypothesis that D-allele and DD-genotype of rs35569394 have deleterious effect on the progression of DR. C-allele had skewed frequency towards DR III subjects owing to strong linkage disequilibrium between C-allele (rs699947) and D-allele (rs35569394).PMID:34693874 | DOI:10.1080/13816810.2021.1992786
Source: Ophthalmic Genetics - Category: Opthalmology Authors: Source Type: research
Type 2 Diabetes Mellitus (T2DM) is a rapidly evolving global pandemic with Asia being its epicentre [1]. Hyperglycemia affects the entire vascular tree giving rise to both macrovascular and microvascular complications that increase both morbidity and mortality associated with diabetes. Diabetic Retinopathy (DR) is an important microvascular complication affecting the retina leading to irreversible blindness among working age individuals around the world [2]. However, the prevalence of DR has been reported to be lower in Asians compared to their western counterparts [3].
Source: Primary Care Diabetes - Category: Primary Care Authors: Tags: Original research Source Type: research
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