Molecules, Vol. 26, Pages 6440: Antiviral Potential of Naphthoquinones Derivatives Encapsulated within Liposomes

Molecules, Vol. 26, Pages 6440: Antiviral Potential of Naphthoquinones Derivatives Encapsulated within Liposomes Molecules doi: 10.3390/molecules26216440 Authors: Viveca Giongo Annarita Falanga Camilly P. Pires De Melo Gustavo B. da Silva Rosa Bellavita Salvatore G. De-Simone Izabel C. Paixão Stefania Galdiero HSV infections, both type 1 and type 2, are among the most widespread viral diseases affecting people of all ages. Their symptoms could be mild, with cold sores up to 10 days of infection, blindness and encephalitis caused by HSV-1 affecting immunocompetent and immunosuppressed individuals. The severe effects derive from co-evolution with the host, resulting in immune evasion mechanisms, including latency and growing resistance to acyclovir and derivatives. An efficient alternative to controlling the spreading of HSV mutations is the exploitation of new drugs, and the possibility of enhancing their delivery through the encapsulation of drugs into nanoparticles, such as liposomes. In this work, liposomes were loaded with a series of 2-aminomethyl- 3-hydroxy-1,4-naphthoquinones derivatives with n-butyl (compound 1), benzyl (compound 2) and nitrobenzene (compound 3) substituents in the primary amine of naphthoquinone. They were previously identified to have significant inhibitory activity against HSV-1. All of the aminomethylnaphthoquinones derivatives encapsulated in the phosphatidylcholine liposomes were able to control the early and late phases of...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research