Pancreatic cancer: The 'difficult' warning sign immediately after having a poo - signs

PANCREATIC cancer develops when cancerous cells in the pancreas - an organ in the top part of your tummy - divide and multiply uncontrollably. One telltale sign of this process can surface immediately after having a poo.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news

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Condition:   Pancreatic Cancer Intervention:   Other: Questionnaire Sponsor:   Taipei Veterans General Hospital, Taiwan Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Background aims: While irresectable pancreatic cancer has still a dismal overall prognosis, evidence about the optimal chemotherapy sequence is scarce. After treatment with FOLFIRINOX in first-line, Gemcitabine-monotherapy was established for years. As a potential treatment alternative after failure of FOLFIRINOX therapy, combination of Gemcitabine and Nab-Paclitaxel is used. However, this combination has formally not yet been approved for second-line treatment and investigation of efficiency and treatment tolerance is the aim of this trial. Methods: Therefore, we investigated 225 patients with histologically confirmed lo...
Source: Oncology Research and Treatment - Category: Cancer & Oncology Source Type: research
Matthias Dobbelstein To improve the treatment of pancreatic ductal adenocarcinoma (PDAC), a promising strategy consists of personalized chemotherapy based on gene expression profiles. Investigating a panel of PDAC-derived human cell lines, we found that their sensitivities towards cisplatin fall in two distinct classes. The platinum-sensitive class is characterized by the expression of GATA6, miRNA-200a, and miRNA-200b, which might be developable as predictive biomarkers. In the case of resistant PDAC cells, we identified a synergism of cisplatin with HSP90 inhibitors. Mechanistic explanations of this synergy include t...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
Swijnenburg Pancreatic ductal adenocarcinoma (PDAC) has an inauspicious prognosis, mainly due to difficulty in early detection of the disease by the current imaging modalities. The upcoming development of tumour-specific tracers provides an alternative solution for more accurate diagnostic imaging techniques for staging and therapy response monitoring. The future goal to strive for, in a patient with PDAC, should definitely be first to receive a diagnostic dose of an antibody labelled with a radionuclide and to subsequently receive a therapeutic dose of the same labelled antibody with curative intent. In the first part...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
Conclusions. CTC presence in PV could be an important prognostic factor to predict poor prognosis in early pancreatic cancer. In addition, the number of clustered-CTC correlate to a tumor negative differentiation degree and, therefore, could be used as a diagnostic biomarker for pancreatic cancer.
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
Scott The development of drug resistance remains one of the greatest clinical oncology challenges that can radically dampen the prospect of achieving complete and durable tumour control. Efforts to mitigate drug resistance are therefore of utmost importance, and nanotechnology is rapidly emerging for its potential to overcome such issues. Studies have showcased the ability of nanomedicines to bypass drug efflux pumps, counteract immune suppression, serve as radioenhancers, correct metabolic disturbances and elicit numerous other effects that collectively alleviate various mechanisms of tumour resistance. Much of this p...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
Surg Innov. 2021 Dec 4:15533506211062398. doi: 10.1177/15533506211062398. Online ahead of print.NO ABSTRACTPMID:34866470 | DOI:10.1177/15533506211062398
Source: Surgical Innovation - Category: Surgery Authors: Source Type: research
CONCLUSION: Despite the methodological challenges and heterogeneity within and across jurisdictions, we demonstrated that mPPP offers a way to compare economic evaluations across jurisdictions.PMID:34866529 | DOI:10.1080/13696998.2021.2007705
Source: Journal of Medical Economics - Category: Health Management Authors: Source Type: research
Adv Radiat Oncol. 2021 Oct 29;7(1):100832. doi: 10.1016/j.adro.2021.100832. eCollection 2022 Jan-Feb.ABSTRACTPURPOSE: The National Comprehensive Cancer Network (NCCN) clinical guidelines influence medical practice, payor coverage, and standards of care. The levels of evidence underlying radiation therapy recommendations in NCCN have not been systematically explored. Herein, we aim to systematically investigate the NCCN recommendations pertaining to the categories of consensus and evidence (CE) for radiation therapy.METHODS AND MATERIALS: We evaluated the distribution of CE underlying current treatment recommendations for t...
Source: Adv Data - Category: Epidemiology Authors: Source Type: research
CONCLUSION: We succeeded in screening differential metabolite ions among PC and DM patients and healthy individuals, thus providing a preliminary basis for screening the biomarkers for the early diagnosis of PC.PMID:34868309 | PMC:PMC8639267 | DOI:10.1155/2021/9990768
Source: International Journal of Endocrinology - Category: Endocrinology Authors: Source Type: research
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