Spinal glial cells in itch modulation

Astrocytes are activated in response to skin inflammation and then enhance itch-specific GRPR signaling in the spinal dorsal horn, which exacerbates chronic itch. AbstractGlial cells are non-neuronal cells in the nervous system that are electrically non-excitable and outnumber neurons in humans. Glial cells have attracted attention in recent years for their active involvement in the regulation of neuronal activity, suggesting their contribution to the pathogenesis and progression of neurological diseases. Studies have shown that astrocytes, a type of glial cell, are activated in the spinal cord in response to skin inflammation and contribute to the exacerbation of chronic itch. This review summarizes the current knowledge about the role of astrocytes and other glial cells in the modulation of itch processing and the mechanism of their activation under itch conditions.
Source: Pharmacology Research and Perspectives - Category: Drugs & Pharmacology Authors: Tags: INVITED REVIEW Source Type: research