Effects of transurethral resection under general anesthesia on tumor recurrence in non-muscle invasive bladder cancer

ConclusionsThe RFS rate was lower in NMIBC patients who received GA during TURBT than in those who received SA. Volatile anesthesia may increase tumor recurrence, particularly in high-risk NMIBC patients, which may be due to the inhibition of the immune response system during surgery.
Source: International Journal of Clinical Oncology - Category: Cancer & Oncology Source Type: research

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Urol Oncol. 2020 Oct 23:S1078-1439(20)30477-4. doi: 10.1016/j.urolonc.2020.10.004. Online ahead of print.ABSTRACTNon-muscle-invasive bladder cancer is one of the most common malignancies. Patients with intermediate-risk or high-risk disease can be treated with intravesical Bacillus Calmette-Guerin, a vaccine against tuberculosis. However, many of these patients will experience tumor recurrence, despite appropriate treatment. 1 The standard of care in these patients is radical cystectomy (RC) with urinary diversion. 2 Patients diagnosed with muscle-invasive bladder cancer (MIBC) have traditionally faced 2 main treatment opt...
Source: Urologic Oncology - Category: Urology & Nephrology Authors: Source Type: research
RARITAN, N.J., November 4, 2021 – The Janssen Pharmaceutical Companies of Johnson &Johnson announced today that more than 45 company-sponsored abstracts, including 11 oral presentations, plus more than 35 investigator-initiated studies will be featured at the American Society of Hematology (ASH) Annual Meeting and Exposition. ASH is taking place at the Georgia World Congress Center in Atlanta and virtually from December 11-14, 2021.“We are committed to advancing the science and treatment of hematologic malignancies and look forward to presenting the latest research from our robust portfolio and pipeline dur...
Source: Johnson and Johnson - Category: Pharmaceuticals Tags: Innovation Source Type: news
We report the case of a 66-year-old man who presented with altered bowel habit and loss of weight, with elevated prostate-specific antigen of 180.6 ng/mL. Sigmoidoscopy showed thickened rectal mucosa, and biopsy was negative for malignancy. Magnetic resonance imaging showed circumferential wall thickening, “target sign” appearance suggestive of RLP, PIRADS 5 lesion with extraprostatic extension, infiltrating bilateral seminal vesicles, and right neurovascular bundle. Repeat colonoscopy was performed under anesthesia, and deeper biopsy revealed poorly differentiated metastatic prostate adenocarcinoma. This case ...
Source: Urology Annals - Category: Urology & Nephrology Authors: Source Type: research
CONCLUSION: This retrospective study shows that antegrade ureteral stent insertion has a high success rate with minimal complications.TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT04649970. Registered december 2, 2020- Retrospectively registered, https://clinicaltrials.gov/ct2/show/NCT04649970.PMID:34466220 | PMC:PMC8382984 | DOI:10.1016/j.amsu.2021.102726
Source: Annals of Medicine - Category: Internal Medicine Authors: Source Type: research
ConclusionsThe RFS rate was lower in NMIBC patients who received GA during TURBT than in those who received SA. Volatile anesthesia may increase tumor recurrence, particularly in high-risk NMIBC patients, which may be due to the inhibition of the immune response system during surgery.
Source: International Journal of Clinical Oncology - Category: Cancer & Oncology Source Type: research
Conclusions: The risk of complications after RC is not related to the type of urinary diversion, and can be reduced by using a minimally invasive surgical technique, especially in patients with high BMI.Urol Int
Source: Urologia Internationalis - Category: Urology & Nephrology Source Type: research
CONCLUSION: The advantages of IF appear to include shorter postoperative hospital stays and higher success rates at a single session, while the advantages of SVAE seem to include non-requirement of spinal/general anesthesia, easy repeatability, and low complication rates. In the management of patients with intractable hematuria, patients' general condition, comorbidities, and anesthesia-related risks should be taken into consideration.PMID:34332813 | DOI:10.1016/j.acuro.2020.11.009
Source: Actas Urologicas Espanolas - Category: Urology & Nephrology Authors: Source Type: research
CONCLUSIONS: Lymphatic flow in metastatic lymph nodes decreased by spinal anesthesia compared to general anesthesia evaluated by using doppler ultrasound in our study. Although this new mechanism is new in the reduction of lymphatic metastasis during cancer surgery, prospective randomized studies evaluating long-term recurrence and survival are warranted.PMID:34318913 | DOI:10.14744/agri.2020.05658
Source: Agri Dergisi - Category: Anesthesiology Authors: Source Type: research
CONCLUSION: Our study is the first to report radical cystectomy outcomes in New Zealand. Alt-hough the perioperative outcomes were comparable to other published series, the subsequent development of metastatic disease remains a problem, with poor five-year survival rates.PMID:34320616
Source: New Zealand Medical Journal - Category: General Medicine Authors: Source Type: research
CONCLUSIONS: Lymphatic flow in metastatic lymph nodes decreased by spinal anesthesia compared to general anesthesia evaluated by using doppler ultrasound in our study. Although this new mechanism is new in the reduction of lymphatic metastasis during cancer surgery, prospective randomized studies evaluating long-term recurrence and survival are warranted.PMID:34318913 | DOI:10.14744/agri.2020.05658
Source: Agri Dergisi - Category: Anesthesiology Authors: Source Type: research
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