Antibody dependent enhancement: Unavoidable problems in vaccine development

This article focuses on the virus-induced ADE phenomenon and its molecular mechanism. It also summarizes various attempts in vaccine research and development to eliminate the ADE phenomenon, and proposes to avoid ADE in vaccine development from the perspective of antigens and adjuvants.PMID:34656289 | PMC:PMC8438590 | DOI:10.1016/bs.ai.2021.08.003
Source: Advances in Immunology - Category: Allergy & Immunology Authors: Source Type: research

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Expert Rev Anti Infect Ther. 2021 Dec 2. doi: 10.1080/14787210.2022.2013808. Online ahead of print.ABSTRACTINTRODUCTION: In solid organ transplant (SOT) recipients, viral infections are associated with direct morbidity and mortality and may influence long-term allograft outcomes. Prevention of viral infections by vaccination, antiviral prophylaxis, and behavioral measures is therefore of paramount importance.AREAS COVERED: We searched Pubmed to select publications to review current preventive strategies against the most important viral infections in SOT recipients, including SARS-CoV-2, influenza, CMV and other herpesvirus...
Source: Expert Review of Anti-Infective Therapy - Category: Infectious Diseases Authors: Source Type: research
Ann Med. 2021 Dec;53(1):2286-2297. doi: 10.1080/07853890.2021.2009128.ABSTRACTThe current COVID-19 global pandemic continues to impact healthcare services beyond those directly related to the management of SARS-CoV-2 transmission and disease. We reviewed the published literature to assess the pandemic impact on existing global immunization activities and how the impact may be addressed. Widespread global disruption in routine childhood immunization has impacted a majority of regions and countries, especially in the initial pandemic phases. While data indicate subsequent recovery in immunization rates, a substantial number ...
Source: Annals of Medicine - Category: Internal Medicine Authors: Source Type: research
Expert Rev Anti Infect Ther. 2021 Dec 2. doi: 10.1080/14787210.2022.2013808. Online ahead of print.ABSTRACTINTRODUCTION: In solid organ transplant (SOT) recipients, viral infections are associated with direct morbidity and mortality and may influence long-term allograft outcomes. Prevention of viral infections by vaccination, antiviral prophylaxis, and behavioral measures is therefore of paramount importance.AREAS COVERED: We searched Pubmed to select publications to review current preventive strategies against the most important viral infections in SOT recipients, including SARS-CoV-2, influenza, CMV and other herpesvirus...
Source: Expert Review of Anti-Infective Therapy - Category: Infectious Diseases Authors: Source Type: research
This report describes progress toward World Health Assembly milestones and measles elimination objectives during 2000-2020 and updates a previous report (2). During 2000-2010, estimated MCV first dose (MCV1) coverage increased globally from 72% to 84%, peaked at 86% in 2019, but declined to 84% in 2020 during the COVID-19 pandemic. All countries conducted measles surveillance, although fewer than one third achieved the sensitivity indicator target of ≥2 discarded†† cases per 100,000 population in 2020. Annual reported measles incidence decreased 88% during 2000-2016, from 145 to 18 cases per 1 million popu...
Source: MMWR Morb Mortal Wkl... - Category: Epidemiology Authors: Source Type: research
The COVID-19 pandemic has cost the global economy trillions of dollars. If the international community invested even a fraction of that money into things like disease surveillance, vaccine manufacturing and better medications, it would slash the chances of another, similar pandemic, philanthropist Bill Gates argued in a conversation with TIME. Prior to the COVID-19 pandemic, “We lost our attention to the preparedness and we got lucky that some of the tools worked”—namely mRNA vaccines. We can’t rely on that kind of luck next time, Gates says. Gates also discussed pandemic preparedness in a Nov. 8 sp...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized COVID-19 healthscienceclimate Source Type: news
Now that the U.S. Food and Drug Administration has authorized Pfizer-BioNTech’s vaccine for kids aged 5 to 11, the Biden Administration has signaled that it will rely on a “trusted messenger” to get information to parents and provide access to vaccines once they’re approved by the Centers for Disease Control and Prevention: schools. As part of the plan to deliver COVID-19 vaccines to the youngest population yet, schools will again take on a role they’ve assumed during health crises throughout American history: promoting vaccination to keep kids and communities safe from infectious disease. &ld...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized COVID-19 healthscienceclimate Source Type: news
It’s time for my healthy nine-year-old son to get vaccinated against COVID-19. In fact, it’s time for every kid aged five to eleven to get vaccinated. An advisory committee to the Food and Drug Administration (FDA) has reviewed the data from clinical trials assessing the safety and efficacy of the Pfizer-BioNTech vaccine in children five to eleven years old. The experts voted unanimously to recommend authorization for this vaccine in children in that age range. As a next step, the Centers for Disease Control and Prevention (CDC) will decide whether all kids should have access to the vaccine, or only some. Some ...
Source: TIME: Health - Category: Consumer Health News Tags: Uncategorized COVID-19 Source Type: news
This report, which updates a previous report (2), presents global, regional,* and national vaccination coverage estimates and trends as of 2020. Changes are described in vaccination coverage and the numbers of unvaccinated and undervaccinated children as measured by receipt of the first and third doses of diphtheria, tetanus, and pertussis-containing vaccine (DTP) in 2020, when the COVID-19 pandemic began, compared with 2019. Global estimates of coverage with the third dose of DTP (DTP3) and a polio vaccine (Pol3) decreased from 86% in 2019 to 83% in 2020. Similarly, coverage with the first dose of measles-containing vacci...
Source: MMWR Morb Mortal Wkl... - Category: Epidemiology Authors: Source Type: research
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