Isotopic Scintigraphy in Intrathecal Drug Delivery Failure: A Single ‐Institution Case Series

ConclusionsTwenty-two abnormalities were identified in 21 examinations, with these abnormalities consisting of leakage (n = 7), spinal catheter obstruction (n = 7), and cerebrospinal fluid flow obstruction (n = 8). Interventions (n = 19) confirmed the cause of ITDD failure. A false-positive finding at follow-up (n = 1) and a false-negative finding (n = 1) were encountered. Sensitivity was 95% (20/21) and the specificity 93% (14/15). A significant difference (p <  0.001) was found between the accuracy of the conventical and the optimized analysis. The optimized111In-DTPA SPECT-CT examination is a powerful diagnostic tool for detecting the cause of ITDD failure.

Source: Neuromodulation: Technology at the Neural Interface - October 22, 2021 Category: Biotechnology Authors: Elmar M. Delhaas, Dani ëlle M.E. Assema, Alida C. Fröberg, Ben G.J.C. Zwezerijnen, Biswadjiet S. Harhangi, Sander P.G. Frankema, Frank J.P.M. Huygen, Aad Lugt Tags: Clinical Research Source Type: research