FDA approves Roche ’s Susvimo, a first-of-its-kind therapeutic approach for neovascular or “wet” age-related macular degeneration (nAMD)

Basel, 22 October 2021 - Roche (SIX: RO, ROG; OTCQX: RHHBY) today announced that the U.S. Food and Drug Administration (FDA) has approved Susvimo ™ (ranibizumab injection) 100 mg/mL for intravitreal use via ocular implant for the treatment of people with neovascular or “wet” age-related macular degeneration (nAMD) who have previously responded to at least two anti-vascular endothelial growth factor (VEGF) injections. Neovascular AMD is a potentially blinding condition that requires treatment with eye injections as often as once a month.1,2,3,4 Susvimo, previously called Port Delivery System with ranibizumab, is the first and only FDA-approved treatment for nAMD that offers as few as two treatments per year.5,6
Source: Roche Media News - Category: Pharmaceuticals Source Type: news

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Contributors : Cody Kime ; Ivo Ngundu Woogeng ; Yoshiki Sahara ; Imad Abugessaisa ; Akira HasegawaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensRegenerative medicine relies on basic research to find safe and useful outcomes that are only practical when cost-effective. The human eyeball requires the retinal pigment epithelium (RPE) for support and maintenance that interfaces the neural retina and the choroid at large. Nearly 200 million people suffer from age-related macular degeneration (AMD), a blinding multifactor genetic disease among other retinal pathologies related to RPE degr...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Nature, Published online: 01 December 2021; doi:10.1038/d41586-021-03574-4A raft of approaches for preventing loss of vision owing to this disease are showing their mettle in clinical trials.
Source: Nature AOP - Category: Research Authors: Source Type: research
Nature, Published online: 01 December 2021; doi:10.1038/d41586-021-03575-3People who develop the dry form of age-related macular degeneration (AMD) currently have no effective options for preserving their vision. But several promising therapeutic avenues are being explored that might just change that.
Source: Nature AOP - Category: Research Authors: Source Type: research
Smoking or consuming alcohol was causally linked with an increased risk of advanced age-related macular degeneration, while smoking cessation decreased the risk of developing advanced AMD.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Ophthalmology News Source Type: news
Epigenetic mechanisms modulate gene expression and function without altering the base sequence of DNA. These reversible, heritable, and environment-influenced mechanisms generate various cell types during development and orchestrate the cellular responses to external stimuli by regulating the expression of genome. Also, the epigenetic modifications influence common pathological and physiological responses including inflammation, ischemia, neoplasia, aging and neurodegeneration etc. In recent past, the field of epigenetics has gained momentum and become an increasingly important area of biomedical research As far as eye is ...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
J Ophthalmic Vis Res. 2021 Oct 25;16(4):670-675. doi: 10.18502/jovr.v16i4.9757. eCollection 2021 Oct-Dec.ABSTRACTAge-related macular degeneration and its complication, subretinal neovascularization, are common causes of progressive, irreversible impairment of central vision. Anti-vascular endothelial growth factor (anti-VEGF) therapy has improved the visual outcome and provided an evolution in the treatment of retinal disease. The current four anti-VEGF drugs - pegaptanib, ranibizumab, aflibercept, and bevacizumab - have been administered for many years. A new anti-VEGF agent, brolucizumab, was approved by the U.S. Food an...
Source: Journal of Ophthalmic and Vision Research - Category: Opthalmology Authors: Source Type: research
J Ophthalmic Vis Res. 2021 Oct 25;16(4):657-669. doi: 10.18502/jovr.v16i4.9756. eCollection 2021 Oct-Dec.ABSTRACTIntravitreal methotrexate (MTX) has been proven to be an effective treatment for various intraocular diseases. In this article, a comprehensive review was performed on intravitreal applications of methotrexate. Different aspects of the administration of intravitreal MTX for various clinical conditions such as intraocular tumors, proliferative vitreoretinopathy, diabetic retinopathy, age-related macular degeneration, and uveitis were reviewed and the adverse effects of intravitreal injection of MTX were discussed...
Source: Journal of Ophthalmic and Vision Research - Category: Opthalmology Authors: Source Type: research
CONCLUSION: AVMD occurs in the same demographic as age-related macular degeneration (AMD) and has many common features. SRF in AVMD tends to be center involving and recurs usually in the same location as its origin. The use of anti-VEGF injections did not seem to improve SRF in contrast to the SRF seen in wet AMD. Proper differentiation of AVMD may prevent unnecessary long-term treatment with intravitreal anti-VEGF injections.PMID:34840681 | PMC:PMC8593535 | DOI:10.18502/jovr.v16i4.9748
Source: Journal of Ophthalmic and Vision Research - Category: Opthalmology Authors: Source Type: research
Free Radic Biol Med. 2021 Nov 26:S0891-5849(21)00824-8. doi: 10.1016/j.freeradbiomed.2021.11.026. Online ahead of print.ABSTRACTLate-stage dry age-related macular degeneration (AMD) or geographic atrophy (GA) is an irreversible blinding condition characterized by degeneration of retinal pigment epithelium (RPE) and the associated photoreceptors. Clinical and genetic evidence supports a role for dysfunctional lipid processing and accumulation of harmful oxidized lipids in the pathogenesis of GA. Using oxidized low-density lipoprotein (ox-LDL)-induced RPE death assay, we screened and identified sterically-hindered phenol com...
Source: Free Radical Biology and Medicine - Category: Biology Authors: Source Type: research
Exp Eye Res. 2021 Nov 26:108860. doi: 10.1016/j.exer.2021.108860. Online ahead of print.ABSTRACTThe Rapid Eye Movement (REM) phase of sleep, also known as "active sleep" because of physiological similarities to waking state, is characterized by intense cerebral electrical activity, propensity to dream vividly and suppression of skeletal muscle activity (atonia) except for the extraocular muscles that give rise to the so-called REM. In 1998 David Maurice, an ophthalmologist, proposed that REM sleep was associated with an eye function: it would be required to stir the anterior chamber and bath it with aqueous humor...
Source: Experimental Eye Research - Category: Opthalmology Authors: Source Type: research
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