Prognostic value of baseline imaging and clinical features in patients with advanced hepatocellular carcinoma

British Journal of Cancer, Published online: 22 October 2021; doi:10.1038/s41416-021-01577-6Prognostic value of baseline imaging and clinical features in patients with advanced hepatocellular carcinoma
Source: British Journal of Cancer - Category: Cancer & Oncology Authors: Source Type: research

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CONCLUSIONS: VEGF is highly expressed in patients with HCC and lowly expressed in patients with AD. VEGF has opposite opposing roles in the treatment of tumors and cognitive impairment.PMID:34845413 | PMC:PMC8627334 | DOI:10.1155/2021/3422393
Source: Computational and Mathematical Methods in Medicine - Category: Statistics Authors: Source Type: research
CONCLUSION: All modalities assessed resulted in similar OS, which explains the current heterogenous practice patterns. This conclusion may assist in decision making based on administrative and patient costs, and implementation of these modalities. Other factors such as toxicity rate specific to individual patients could not be assessed using network meta-analysis and may also play a role in selection of modality. Further studies, ideally using PSM cohort analyses or RCT study design, reporting on OS, PFS, local control, complete response and toxicity are needed prior to drawing definitive conclusions.PMID:34846988 | DOI:10...
Source: Acta Oncologica - Category: Cancer & Oncology Authors: Source Type: research
ConclusionSNHG1 is a promising prognostic factor in HCC, and the SNHG1–miR-326–LMNB2 axis may be a potential therapeutic target for HCC.
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Conclusions: This gene signature may be useful prognostic markers and therapeutic targets in patients with HCC.
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
Hepatocellular carcinoma (HCC) is one of the most common malignancies and ranks as the second leading cause of cancer-related mortality worldwide. Heat shock factor 2 (HSF2) is a transcription factor that plays a critical role in development, particularly corticogenesis and spermatogenesis. However, studies examining the expression and prognostic value of HSF2 and its association with tumor-infiltrating immune cells in HCC are still rare. In the present study, we found that HSF2 expression was significantly upregulated in HCC tissues compared with normal liver tissues using the TCGA, ICGC, GEO, UALCAN, HCCDB and HPA databa...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
Conclusion: We established a reliable hypoxia-related lncRNAs signature that could accurately predict the clinical outcomes of HCC patients and correlate with immunotherapy response and targeted drug sensitivity, providing new insights for immunotherapy and targeted therapy in HCC.
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
Carlo V. Catapano The multi-kinase inhibitor sorafenib is a primary treatment modality for advanced-stage hepatocellular carcinoma (HCC). However, the therapeutic benefits are short-lived due to innate and acquired resistance. Here, we examined how HCC cells respond to sorafenib and adapt to continuous and prolonged exposure to the drug. Sorafenib-adapted HCC cells show a profound reprogramming of mitochondria function and marked activation of genes required for mitochondrial protein translation and biogenesis. Mitochondrial ribosomal proteins and components of translation and import machinery are increased in sorafe...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
This study involved 201 cases divided: Group I (67 HCC patients), Group II (67 cirrhotic patients), Group III (67 control). Each group was subjected to laboratory investigations: (CBC, blood sugar, kidney and liver function, viral markers, alpha fetoprotein), imaging: (abdominal ultrasonography, and triphasic C.T) and ADAM 10 gene polymorphism (rs 653765, rs 383902) detection by real – time PCR. Results: There was a statistically significant difference in the frequency and genotyping of ADAM10 SNPs in HCC patients in comparison to cirrhotic and control groups [the frequency of rs 653765 genotypes (p=0.015) and model ...
Source: Current Cancer Therapy Reviews - Category: Cancer & Oncology Source Type: research
This study mainly explores the difference in clinical characteristics between hepatitis B-related hepatocellular carcinoma and alcohol-related hepatocellular carcinoma. Through comparative analysis and analysis of the clinical characteristics of hepatitis B and alcohol-related liver cancer, the study found that hepatitis B and alcohol-related liver cancer have obvious differences in their impact mechanisms. Therefore, targeted prevention and diagnosis and treatment measures can be put forward on this basis to provide a theoretical reference for subsequent clinical treatment analysis of liver cancer.PMID:34840599 | PMC:PMC8...
Source: Computational and Mathematical Methods in Medicine - Category: Statistics Authors: Source Type: research
The objective of this investigation was to determine the efficacy of radiotherapy in patients with HCC invading distant organs.METHODS: The data of 2342 patients diagnosed between 2010 and 2015 with HCC invading distant organs were extracted from the SEER database. Propensity score matching (PSM) was used to reduce selection bias.RESULTS: Before PSM, the median overall survival (mOS) and median cancer-specific survival (mCSS) in the radiotherapy group (mOS = 5 months, 95% CI: 4.5-5.5; mCSS = 5 months, 95% CI: 4.4-5.6) were longer than those in the nonradiotherapy group (mOS = 3 months, 95% CI: 2.8-3.2; mCSS = 3 months, 95% CI: 2.8-3.2; both P
Source: Journal of Oncology - Category: Cancer & Oncology Authors: Source Type: research
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