Investigating single amino acid substitutions in PIM1 kinase: A structural genomics approach

This study prov ides a significant insight into the PIM1 dysfunction upon single amino acid substitutions, which can be utilized to get insights into the molecular basis of PIM1-associated disease progression.
Source: PLoS One - Category: Biomedical Science Authors: Source Type: research

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Conclusion: In this study, we report data from 630 patients who were undergoing treatment with alpha-emitting isotopes 223Ra and 225Ac. While alpha emitters have ability to deliver higher internal radiation dose to the tissues exposed as compared with other unsealed radionuclides, they typically present minimal external dose rate concerns. Additionally, alpha radiation can be efficiently detected with appropriate radiation instrumentation, such as a liquid scintillation counter or ZnS probe, that should be prioritized when surveying for spills of alpha-emitters.PMID:34750237 | DOI:10.2967/jnmt.121.262294
Source: Journal of Nuclear Medicine Technology - Category: Nuclear Medicine Authors: Source Type: research
sen Exemplified by infections with bovine meat and milk factors (BMMFs), this manuscript emphasizes the different mechanistic aspects of infectious agents contributing to human cancers by “direct” or “indirect” interactions. The epidemiology of cancers linked to direct carcinogens (e.g., response to immunosuppression) differs from those cancers linked with indirect infectious interactions. Cancers induced by direct infectious carcinogens commonly increase under immunosuppression, whereas the cancer risk by indirect carcinogens is reduced. This influences their responses to preventive and therape...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
Cancers, Vol. 13, Pages 3060: Structure vs. Function of TRIB1—Myeloid Neoplasms and Beyond Cancers doi: 10.3390/cancers13123060 Authors: Hamish D McMillan Karen Keeshan Anita K Dunbier Peter D Mace The Tribbles family of proteins—comprising TRIB1, TRIB2, TRIB3 and more distantly related STK40—play important, but distinct, roles in differentiation, development and oncogenesis. Of the four Tribbles proteins, TRIB1 has been most well characterised structurally and plays roles in diverse cancer types. The most well-understood role of TRIB1 is in acute myeloid leukaemia, where it can regulate C/E...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
Appl Biochem Biotechnol. 2021 Mar 10. doi: 10.1007/s12010-021-03537-5. Online ahead of print.ABSTRACTCytosine methylation is a well-explored epigenetic modification mediated by DNA methyltransferases (DNMTs) which are considered "methylation writers"; cytosine methylation is a reversible process. The process of removal of methyl groups from DNA remained unelucidated until the discovery of ten-eleven translocation (TET) proteins which are now considered "methylation editors." TET proteins are a family of Fe(II) and alpha-ketoglutarate-dependent 5-methyl cytosine dioxygenases-they convert 5-methyl cytosin...
Source: Applied Biochemistry and Biotechnology - Category: Biochemistry Authors: Source Type: research
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