Roe-inspired stem cell microcapsules for inflammatory bowel disease treatment Engineering

Mesenchymal stem cells (MSCs), which exert regulatory effects on various immune cells, have been a promising therapy for inflammatory bowel disease treatment. However, their therapeutic effects are limited by lack of nutritional supply, immune system attack, and low accumulation on the target site. Here, inspired by the natural incubation mechanism...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Tags: Engineering Physical Sciences Source Type: research

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Asian Pac J Cancer Prev. 2021 Nov 1;22(11):3577-3583. doi: 10.31557/APJCP.2021.22.11.3577.ABSTRACTBACKGROUND AND AIM: Cancer stem cell markers were thoroughly investigated as a promising strategy for the prediction of patient outcome and therapeutic response. The prospective role of CD44 cell adhesion molecule in tumorigenic potential and its association with the proliferative activity and apoptotic status of Egyptian patients with ulcerative colitis (UC) and colorectal cancer (CRC) were investigated in this study.MATERIAL AND METHOD: Flow cytometric analyses of CD44, DNA cell cycle, and apoptosis identified by Annexin V/P...
Source: Asian Pacific Journal of Cancer Prevention - Category: Cancer & Oncology Authors: Source Type: research
Conditions:   Crohn Disease;   IBS - Irritable Bowel Syndrome Intervention:   Drug: Bone Marrow MSC Derived Extracellular Vesicle Isolate Sponsor:   Direct Biologics, LLC Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
We report this infant with an acquired RVF with extraintestinal features due to IL10RB mutation to highlight the importance of thinking beyond the local anatomy and looking into the genetic domain.
Source: Journal of Indian Association of Pediatric Surgeons - Category: Surgery Authors: Source Type: research
Med Ultrason. 2021 Nov 3. doi: 10.11152/mu-3273. Online ahead of print.ABSTRACTVery early-onset inflammatory bowel disease (VEO-IBD) is defined as IBD onset before 6 years of age and some cases are caused by unique monogenic disorders that require specific treatments such as stem cell transplantation. We identified three children with VEO-IBD of whom two had monogenic disorders. In cases 1 and 2, ultrasound revealed isolated colonic distribution and the loss of wall stratification. In case 3, mesentery inflammation was evident. Bowel ultrasound showed variable findings due to differences in the inflammation distribution wi...
Source: Medical Ultrasonography - Category: Radiology Authors: Source Type: research
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