Evaluating Variation in Perioperative Red Blood Cell Transfusion for Patients Undergoing Elective Gastrointestinal Cancer Surgery: A Population-based Analysis

Patients undergoing gastrointestinal cancer surgery often receive red blood cell (RBC) transfusions. Understanding practice variation is critical to support efforts working towards responsible RBC transfusion use. We aimed to measure the extent and importance of variation in perioperative RBC transfusion use across surgeons and hospitals among gastrointestinal cancer surgery patients.
Source: Journal of the American College of Surgeons - Category: Surgery Authors: Tags: Health Services Research Source Type: research

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Propose of review To summarize the evidence that suggests that osteoarthritis (OA) is a mitochondrial disease. Recent findings Mitochondrial dysfunction together with mtDNA damage could contribute to cartilage degradation via several processes such as: (1) increased apoptosis; (2) decreased autophagy; (3) enhanced inflammatory response; (4) telomere shortening and increased senescence chondrocytes; (5) decreased mitochondrial biogenesis and mitophagy; (6) increased cartilage catabolism; (7) increased mitochondrial fusion leading to further reactive oxygen species production; and (8) impaired metabolic flexibilit...
Source: Current Opinion in Rheumatology - Category: Rheumatology Tags: OSTEOARTHRITIS: Edited by Mukundan Attur Source Type: research
Stomach cancer is one of the least common cancers in the United Kingdom. The estimated lifetime risk of being diagnosed with stomach cancer is at least one in seventy-six for men born after 1960, according to Cancer Research UK. Nevertheless, it is helpful to know the symptoms just in case you start to feel unwell.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Reprod Biol Endocrinol. 2021 Dec 3;19(1):178. doi: 10.1186/s12958-021-00860-8.ABSTRACTOvarian cancer is the fifth leading cause of cancer-related mortality in women worldwide. Despite the development of technologies over decades to improve the diagnosis and treatment of patients with ovarian cancer, the survival rate remains dismal, mainly because most patients are diagnosed at a late stage. Traditional treatment methods and biomarkers such as cancer antigen-125 as a cancer screening tool lack specificity and cannot offer personalized combinatorial therapy schemes. Circulating tumor DNA (ctDNA) is a promising biomarker for...
Source: Reproductive Biology - Category: Reproduction Medicine Authors: Source Type: research
In this study, we explored whether LA has an anti-aging effect in adipose-derived stem cells (ADSCs). We performed β-galactosidase staining and measured reactive oxygen species, relative telomere lengths, and P16ink4a mRNA expression. Osteogenesis was assessed by Alizarin Red staining and adipogenesis by was assessed Oil Red O staining. Protein levels of related markers runt-related transcription factor 2 and lipoprotein lipase were also examined. RNA sequencing and measurement of glycolysis activities showed that LA significantly activated glycolysis in ADSCs. Together, our data strongly suggest that the LA have an a...
Source: Aging - Category: Biomedical Science Authors: Source Type: research
Aging (Albany NY). 2021 Dec 3;13(undefined). doi: 10.18632/aging.203733. Online ahead of print.ABSTRACTCircadian dysregulation involves malignant tumor initiation and progression, but the understanding of circadian rhythm's roles in bladder cancer (BCa) remains insufficient. The circadian rhythm-related genes were collected and clustered based on the Cancer Genome Atlas (TCGA), and the clustering was significantly associated with the prognosis and risk clinicopathological features. Through genomic difference analysis and gene pairing, a circadian rhythm-related signature was successfully established. Kaplan-Meier survival ...
Source: Aging - Category: Biomedical Science Authors: Source Type: research
Phytother Res. 2021 Dec 4. doi: 10.1002/ptr.7345. Online ahead of print.ABSTRACTDocetaxel (DTX) is used against breast cancer despite its side effects such as toxicity and immunosuppression. Here we investigated the cytotoxic and immunomodulatory effects of the ethanol solution extract of propolis (EEP) in combination with DTX on MCF-7 breast cancer cells and on women's monocyte. The cytotoxic potential of EEP + DTX was assessed by MTT assay and the type of tumor cell death was evaluated by flow cytometry. The effects of EEP + DTX on the migration and invasion of MCF-7 cells were analyzed. Cytokine production by monocytes ...
Source: Cell Research - Category: Cytology Authors: Source Type: research
CONCLUSIONS: Despite lack of clinical efficacy, immune subset analyses suggest that there are additive effects of this combination; however, the associated toxicity limits the feasibility of combination treatment with pembrolizumab and acalabrutinib in patients with recurrent or metastatic HNSCC.PMID:34862248 | DOI:10.1158/1078-0432.CCR-21-2547
Source: Cell Research - Category: Cytology Authors: Source Type: research
CONCLUSION: Overall, our results demonstrate that the detection and persistence of ctDNA at MT may have the potential to negatively predict response to neoadjuvant treatment and identify patients who will not achieve pCR or be classified with RCB II/III.PMID:34862246 | DOI:10.1158/1078-0432.CCR-21-3231
Source: Cell Research - Category: Cytology Authors: Source Type: research
CONCLUSIONS: In this trial, treatment of newly diagnosed and recurrent glioblastoma with autologous dendritic cell vaccine pulsed with lysate derived from an allogeneic stem-like cell line was safe and well-tolerated. Clinical outcomes add to the body of evidence suggesting that immunotherapy plays a role in the treatment of glioblastoma.PMID:34862245 | DOI:10.1158/1078-0432.CCR-21-2867
Source: Cell Research - Category: Cytology Authors: Source Type: research
CONCLUSIONS: These findings suggest that SBRT augmentation of antitumor immunogenicity may be dampened by an overabundance of refractory immunosuppressive populations, and support the continued development of SBRT/immunotherapy combination for human PDAC.PMID:34862242 | DOI:10.1158/1078-0432.CCR-21-2495
Source: Cell Research - Category: Cytology Authors: Source Type: research
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