Copper induces oxidative stress and apoptosis of hippocampal neuron via pCREB/BDNF/ and Nrf2/HO ‐1/NQO1 pathway
In conclusion, we found copper inhibited pCREB/BDNF signaling pathway by prevent CREB from phosphorylation, further found that oxidative damage not only inhibited neuroprotective signaling pathways and induced apoptosis, but activated antioxidant protection signals Nrf2/HO-1/NQO1 signaling pathway.
Source: Journal of Applied Toxicology - Category: Toxicology Authors: Qiang Lu,
Ying Zhang,
Chao Zhao,
Hu Zhang,
Yuepu Pu,
Lihong Yin Tags: RESEARCH ARTICLE Source Type: research
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