A Drug –Drug Interaction Study to Investigate the Effect of Nintedanib on the Pharmacokinetics of Microgynon (Ethinylestradiol and Levonorgestrel) in Female Patients with Systemic Sclerosis-Associated Interstitial Lung Disease

ConclusionPharmacokinetic data indicate that there is no relevant effect of nintedanib on plasma exposure to ethinylestradiol and levonorgestrel in female patients with SSc-ILD.Trial RegistrationClinicaltrials.gov NCT03675581.
Source: European Journal of Drug Metabolism and Pharmacokinetics - Category: Drugs & Pharmacology Source Type: research

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Around 4 million pregnant women have taken the Covid jab ever since the vaccine drive rolled out, which is a minuscule number given that estimates show there are 30 million of them in the country at any point.
Source: The Economic Times Healthcare and Biotech News - Category: Pharmaceuticals Source Type: news
Condition:   Medical Termination of Pregnancy Intervention:   Other: Questionnaire Sponsor:   Hospices Civils de Lyon Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Appendicitis in Pregnancy Intervention:   Sponsor:   Clinical Hospital Centre Zagreb Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
FRIDAY, Jan. 21, 2022 -- Nearly one in three pregnant women have reported elevated symptoms of mental health distress and a negative impact on health behaviors during the COVID-19 pandemic, according to a study published in the January issue of the...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
Funding Opportunity RFA-HD-22-024 from the NIH Guide for Grants and Contracts. The purpose of this funding opportunity announcement (FOA) is to support interdisciplinary community-engaged research designed to reduce or eliminate infections and sepsis as causes of pregnancy-related or associated morbidity and mortality (PRAMM) in regions of the United States with high rates of maternal mortality. This FOA is to support research primarily focused on PRAMM health disparities in areas with highest maternal morbidity and mortality.
Source: NIH Funding Opportunities (Notices, PA, RFA) - Category: Research Source Type: funding
Some recent things you may want to know about:COVID vaccinationUK government urges all pregnant women to get immediate COVID jab (Guardian)Guardian opinion piece on government messaging.  Author is a reproductive immunologist.ResearchAssociation of Antenatal Diet and Physical Activity-Based Interventions With Gestational Weight Gain and Pregnancy Outcomes: A Systematic Review and Meta-analysisEffect of chlorhexidine cleansing on healthcare-associated infections in neonates: a systematic review and meta-analysisTerm infant formula supplemented with milk-derived oligosaccharides shifts the gut microbiota closer to that ...
Source: Browsing - Category: Databases & Libraries Tags: midwifery Source Type: blogs
This study aimed to assess the relationship between the use of the prone position and the development of VILI-associated regional neutrophilic lung inflammation. Regional neutrophilic lung inflammation and lung aeration during low tidal volume mechanical ventilation were assessed using in vivo 2-deoxy-2-[(18)F] fluoro-D-glucose (18F-FDG) positron emission tomography and computed tomography in acutely experimentally injured rabbit lungs (lung injury induced by lung lavage and excessive ventilation). Direct comparisons were made among three groups: control, supine, and prone positions. After approximately 7 h, tissue-norma...
Source: Shock - Category: Emergency Medicine Tags: Basic Science Aspects Source Type: research
Conclusions Local residual disease in BIA-ALCL is bound to be a progressively more common occurrence, as awareness of BIA-ALCL increases and more cases are diagnosed worldwide. Currently, there is no established consensus on a standard approach for the treatment for patients with a higher risk of local recurrence. Our experience describes the protocol we used to successfully manage a case of BIA-ALCL with incomplete surgical margins, which hopefully can serve colleagues treating patients with similar cases.
Source: Annals of Plastic Surgery - Category: Cosmetic Surgery Tags: Breast Surgery Source Type: research
Int J Circumpolar Health. 2022 Dec;81(1):2021684. doi: 10.1080/22423982.2021.2021684.ABSTRACTGiven the dynamic nature of the ongoing pandemic, public knowledge and perceptions about COVID-19 are evolving. Limited transportation options, inconsistent healthcare resources, and lack of water and sanitation infrastructure in many remote Alaskan communities located off the road system have contributed to the experience of the COVID-19 pandemic in these areas. We used longitudinal surveys to evaluate remote Alaskan residents' early vaccine acceptance, vaccine uptake and motivations, risk perceptions regarding COVID-19 vaccines, ...
Source: Rural Remote Health - Category: Rural Health Authors: Source Type: research
ConclusionPharmacokinetic data indicate that there is no relevant effect of nintedanib on plasma exposure to ethinylestradiol and levonorgestrel in female patients with SSc-ILD.Trial RegistrationClinicaltrials.gov NCT03675581.
Source: European Journal of Drug Metabolism and Pharmacokinetics - Category: Drugs & Pharmacology Source Type: research
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