New Approaches to Glioblastoma

Annu Rev Med. 2021 Oct 19. doi: 10.1146/annurev-med-042420-102102. Online ahead of print.ABSTRACTFaced with unique immunobiology and marked heterogeneity, treatment strategies for glioblastoma require therapeutic approaches that diverge from conventional oncological strategies. The selection and prioritization of targeted and immunotherapeutic strategies will need to carefully consider these features and companion biomarkers developed alongside treatment strategies to identify the appropriate patient populations. Novel clinical trial strategies that interrogate the tumor microenvironment for drug penetration and target engagement will inform go/no-go later-stage clinical studies. Innovative trial designs and analyses are needed to move effective agents toward regulatory approvals more rapidly. Expected final online publication date for the Annual Review of Medicine, Volume 73 is January 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.PMID:34665646 | DOI:10.1146/annurev-med-042420-102102
Source: Annual Review of Medicine - Category: General Medicine Authors: Source Type: research