The impact of extended half-life factor concentrates on patient reported health outcome measures in persons with hemophilia A and hemophilia B

CONCLUSION: Switching from SHL to rFVIIIFc/rFIXFc resulted in short-term meaningful improvement in overall HRQoL and other PROMs in a small proportion. Longitudinal changes on PROMs are affected by ceiling effects and response shift, warranting further studies in instrument optimization in the era of EHL and nonfactor products.PMID:34667922 | PMC:PMC8505988 | DOI:10.1002/rth2.12601

Source: Thrombosis and Haemostasis - October 20, 2021 Category: Hematology Authors: Haowei Linda Sun Ming Yang Man-Chiu Poon Adrienne Lee K Sue Robinson Michelle Sholzberg John Wu Alfonso Iorio Victor Blanchette Manuel Carcao Robert J Klaassen Shannon Jackson Source Type: research