Recombinant factor IX-Fc fusion protein in severe hemophilia B: Patient-reported outcomes and health-related quality of life

Res Pract Thromb Haemost. 2021 Oct 11;5(7):e12602. doi: 10.1002/rth2.12602. eCollection 2021 Oct.ABSTRACTINTRODUCTION: In 2017, all people with severe hemophilia B in Ireland switched to recombinant factor IX Fc fusion protein concentrate (rFIXFc) prophylaxis. Patient-reported outcomes (PROs) and health-related quality of life (HRQoL) are important to evaluate with new treatments.AIMS: To assess HRQoL in people with severe hemophilia B and their experience after switching to rFIXFc prophylaxis.METHODS: Participants completed a Patient Reported Outcomes Burden and Experience (PROBE) questionnaire on initiation and following two years of rFIXFc prophylaxis. The PROBE questionnaire has four domains: demographics, general health, haemophilia-specific, and European Quality of Life 5-Dimensions (EQ-5D-5L) questionnaire.RESULTS: Twenty-three participants completed the questionnaire at both time points. The number of activities where chronic pain occurred and interfered with the activity was reduced by 25% and 33%, respectively (P
Source: Thrombosis and Haemostasis - Category: Hematology Authors: Source Type: research

Related Links:

Discussion The hands are one of the most important parts of the body for interacting with the world. They are remarkably adapted having sensitive sensory receptors as well as feedback receptors for grasping, holding, and manipulating objects. Hands, especially with an opposable thumb, multiple joints within the hand, along with the wrist and elbow, allow the hand to move in multiple positions to manipulate the world. Hands also symbolize an emotional caring and sharing between individuals as hands are used to provide a true “human touch” in personal and social situations. Due to their important interactions in ...
Source: - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
NEW BRUNSWICK, N.J., DECEMBER 5, 2021 – Johnson &Johnson (NYSE: JNJ) (the Company) today announced preliminary results from an independent study, including a subset of participants from the Janssen-sponsored COV2008 study, conducted by Dan Barouch, M.D., Ph.D., et al. of Beth Israel Deaconess Medical Center (BIDMC), which showed that a booster shot of the Johnson &Johnson COVID-19 vaccine (Ad26.COV2.S), administered at six months after a two-dose primary regimen of BNT162b2, increased both antibody and T-cell responses. These results demonstrate the potential benefits of heterologous boosting (mix-and-match)....
Source: Johnson and Johnson - Category: Pharmaceuticals Tags: Innovation Source Type: news
In my last post I described the “4 P” model (sometimes called the 5P!) of formulation for pain. In today’s post I want to talk about an integrated approach for a team. Teamwork in pain management is an enormous thing – IASP (International Association for the Study of Pain) endorses multidisciplinary (I prefer interprofessional) teamwork but gives little information on how teams best work together. In fact, research exploring teamwork processes in pain management is remarkably absent, even though there’s considerable research elsewhere in healthcare showing that effective teamwork is quite ...
Source: HealthSkills Weblog - Category: Anesthesiology Authors: Tags: Assessment Chronic pain Clinical reasoning Interdisciplinary teams Professional topics Psychology Research Science in practice biopsychosocial case formulation Health healthcare pain management teamskills teamwork Source Type: blogs
Bob Dole was just 21 years old when he suffered the injuries that would change his life. In April 1945, while stationed in Italy during WWII, the young soldier was struck by enemy fire. As a result of his wounds, Dole was permanently left without feeling in his right hand and arm, which measured more than two inches shorter than his left after reparative surgeries; part of his left hand was also left numb. Dole, who died on Sunday at the age of 98, would live with and be shaped by the aftermath of those injuries in the years that followed, including the 30 he spent as a U.S. senator from Kansas. [time-brightcove not-tgx=&r...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized remembrance Second click Source Type: news
Hi all, I went unmatched cards this year and I am literally devastated and fighting depression at this point. I don't know what to do. I figured a chief resident year would be a fair option. I am unsure where to start looking for those positions though? I found 3 that are at hospitals without a cardiology fellowship which I think would not benefit me that well. I am literally running out of ideas and would appreciate any input on what to do and how to go about things.
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Internal Medicine and IM Subspecialties Source Type: forums
The Fighting Irish came up one spot short of a College Football Playoff berth. The New Year’s Six is next. #ny6 #fightingirish #notredame #thefightingirish #cfp #collegefootball
Source: Reuters: Health - Category: Consumer Health News Source Type: news
Rates of anxiety and depression among college students are at an all-time high and still rising, according to a 2020 study spearheaded by Boston University.
Source: Health Care:Pharmaceuticals headlines - Category: Pharmaceuticals Authors: Source Type: news
In this study, they found these drugs can kill senescent cells from cultures of human fat tissue. The tissue was donated by individuals with obesity who were known to have metabolic troubles. Without treatment, the human fat tissues induced metabolic problems in immune-deficient mice. After treatment with dasatinib and quercetin, the harmful effects of the fat tissue were almost eliminated. Targeting p21Cip1 highly expressing cells in adipose tissue alleviates insulin resistance in obesity Insulin resistance is a pathological state often associated with obesity, representing a major risk factor for type 2...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
AbstractWe thank Rivano-Fischer and St ålnacke (2021) for the time they invested in our study. We believe that most of their criticism was already addressed in our original publication (LoMartire et al., 2021). In this response, we first reply to their comments, then discuss problems with their promoted uncontrolled before-and-after (UB A) design, and finally present target trial emulation as an alternative for observational data. This reply represents the perspective of LoMartire, Constan, and Frumento only.
Source: European Journal of Pain - Category: Anesthesiology Authors: Tags: LETTER TO THE EDITOR Source Type: research
ENDOMETRIOSIS is a painful condition that affects a whopping 1.5 million women in the UK. Some women are so badly affected by symptoms that their daily lives are disrupted by fatigue, chronic pain and declining mental health. One of these women is 26-year-old Florence Ssentongo.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
More News: Anxiety | Arthritis | Chronic Pain | Depression | Gingivitis | Haemophilia | Health Management | Hematology | Hemophilia | Hypertension | Ireland Health | Pain | Rheumatology | Study | Thrombosis