Dietary {omega}-3 polyunsaturated fatty acids are protective for myopia Medical Sciences

Myopia is a leading cause of visual impairment and blindness worldwide. However, a safe and accessible approach for myopia control and prevention is currently unavailable. Here, we investigated the therapeutic effect of dietary supplements of omega-3 polyunsaturated fatty acids (ω-3 PUFAs) on myopia progression in animal models and on decreases...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Tags: Medical Sciences Biological Sciences Source Type: research

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Discussion Uncorrected refractive errors (URE) are a major cause of visual impairment and blindness globally. It is estimated that more than 12.8 million children ages 5-15 years have URE. URE can cause astigmatism, anisometropia, amblyogenic hyperopia and myopia. It can also be a factor in injuries, behavioral problems and academic and social impairments. Spectacles (or eyeglasses or eye wear) are a low-cost, non-invasive, simple to use treatment for URE. Spectacle use has many benefits but depend on end-user use. Learning Point Non-compliance with spectacle use is estimated to be 40.1% overall with a range of 9.8-78.6% i...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
This study evaluated 75 eyes of 48 patients with high myopia (HM), 43 eyes of 31 patients with mild to moderate myopia and 68 eyes of 53 age-matched controls. Controlling for age and the presence of systemic hypertension, we found that HM was associated with decrease in VD and VSD in all layers on 12×12 mm² scans. Furthermore, HM was associated with a VD and VSD decrease in every Early Treatment Diabetic Retinopathy Study grid, with a larger decrease temporally (βVD=-0.39, βVSD=-10.25, p
Source: The British Journal of Ophthalmology - Category: Opthalmology Authors: Source Type: research
J Ophthalmol. 2021 Jul 28;2021:8873283. doi: 10.1155/2021/8873283. eCollection 2021.ABSTRACTPURPOSE: To describe the age distribution and main causes of new registered irreversible visual impairment (VI) and to compare the five-year proportion of VI in Jinshan district, Shanghai, from 2009 to 2018.METHODS: The new irreversible VI data were collected in the registry system from the Disabled Persons' Federation in Jinshan district from January 1, 2009, to December 31, 2018. Age, gender, and causes of VI were included, and the 5-year proportion of VI was calculated.RESULTS: The peak occurrence of blindness occurred in the 50-...
Source: Journal of Ophthalmology - Category: Opthalmology Authors: Source Type: research
Conclusions: Clinical and molecular analyses within the described family demonstrate the possibility of maternal mosaicism in NYX-related CSNB. The importance of cascade molecular testing is highlighted. The prospect of somatic or germline mosaicism in NYX-related CSNB informs genetic counseling, genetic testing decisions, and risk assessment in affected families.PMID:34165036 | DOI:10.1080/13816810.2021.1941129
Source: Ophthalmic Genetics - Category: Opthalmology Authors: Source Type: research
In this study, we investigated the clinical and genetic characteristics of 19 Korean patients with congenital stationary night blindness (CSNB) at two tertiary hospitals. Clinical evaluations, including fundus photography, spectral-domain optical coherence tomography, and electroretinography, were performed. Genetic analyses were conducted using targeted panel sequencing or whole exome sequencing. The median age was 5 (3–21) years at the initial examination, 2 (1–8) years at symptom onset, and 11 (5–28) years during the final visit. Genetic mutations were identified as CNGB1 and GNAT1 for the Riggs type (...
Source: Genes - Category: Genetics & Stem Cells Authors: Tags: Article Source Type: research
Myopic maculopathy (MM) is one of the major causes of visual impairment and irreversible blindness in eyes with pathologic myopia (PM). However, the classification of each type of lesion associated with MM has...
Source: BMC Ophthalmology - Category: Opthalmology Authors: Tags: Research Source Type: research
Conclusions: We identified a novel missense NYX variant in a Japanese family with complete CSNB. Our clinical findings indicated that photoreceptor mediated ERG responses are well preserved even in middle-aged and older adult patients.PMID:33769208 | DOI:10.1080/13816810.2021.1904422
Source: Ophthalmic Genetics - Category: Opthalmology Authors: Source Type: research
This study aimed to assess the prevalence and associated factors of myopia among school children in Bahir Dar city, Northwest Ethiopia, 2019. Methods and materialsA school-based cross-sectional study was conducted among school children of 6 to 18 years of age in Bahir Dar city from October to November 2019. A pretested interviewer-administered structured questionnaire was used to collect data among 634 participants using a multi-stage sampling technique from primary and secondary schools. Cycloplegic refraction was performed by optometrists for each student with 1% cyclopentolate eye drop, and subjective refraction was car...
Source: PLoS One - Category: Biomedical Science Authors: Source Type: research
Ophthalmic Genet. 2021 Mar 10:1-4. doi: 10.1080/13816810.2021.1897846. Online ahead of print.ABSTRACTThe complete form of congenital stationary night blindness (cCSNB) represents a non-progressive retinal disorder characterized by night vision problems and often congenital nystagmus, reduced vision, high myopia, strabismus and normal fundus appearance. Clinically this form of CSNB can be diagnosed by full-field electroretinogram. The mode of inheritance can be X-linked and autosomal recessive with mutations in genes coding for proteins mainly present at the dendritic tips of ON-bipolar cells. Mutations in NYX, GRM6, GPR179...
Source: Ophthalmic Genetics - Category: Opthalmology Authors: Source Type: research
Eur J Ophthalmol. 2021 Mar 5:1120672121998960. doi: 10.1177/1120672121998960. Online ahead of print.ABSTRACTThe prevalence of myopia is increasing extensively worldwide. The number of people with myopia in 2020 is predicted to be 2.6 billion globally, which is expected to rise up to 4.9 billion by 2050, unless preventive actions and interventions are taken. The number of individuals with high myopia is also increasing substantially and pathological myopia is predicted to become the most common cause of irreversible vision impairment and blindness worldwide and also in Europe. These prevalence estimates indicate the importa...
Source: European Journal of Ophthalmology - Category: Opthalmology Authors: Source Type: research
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