Immunotherapeutic advances in gastric cancer

AbstractAdvanced gastric cancers are responsible for overwhelming human suffering and death. Despite the development of combination chemotherapies, the survival rates of patients with gastric cancer remain unsatisfactory. Given the growing evidence of the benefits of immunotherapy as an alternative treatment for other cancers such as advanced melanoma, non-small cell lung cancer, renal cell carcinoma, and refractory Hodgkin ’s lymphoma, researchers have begun to explore its application in the treatment of gastric cancer. Three types of immunotherapy have shown promising effects against gastric cancer: immune checkpoint inhibitors, chimeric antigen rector (CAR)-T cells, and tumor vaccines. Clinical trials have used ei ther immuno-oncology monotherapies or combination immuno-chemotherapies to improve the overall survival times and objective response rates of patients with gastric cancer. We review the clinical efficacy of immunotherapy including checkpoint inhibitors, CAR‑T, and tumor vaccines, in the treatment of gastric cancer. Based on initial evidence, we believe that immunotherapy could positively impact the natural history and improve the outcomes of a subgroup of patients with gastric cancer.
Source: Surgery Today - Category: Surgery Source Type: research

Related Links:

Source: BMJ Comments - Category: General Medicine Source Type: forums
Discussion The hands are one of the most important parts of the body for interacting with the world. They are remarkably adapted having sensitive sensory receptors as well as feedback receptors for grasping, holding, and manipulating objects. Hands, especially with an opposable thumb, multiple joints within the hand, along with the wrist and elbow, allow the hand to move in multiple positions to manipulate the world. Hands also symbolize an emotional caring and sharing between individuals as hands are used to provide a true “human touch” in personal and social situations. Due to their important interactions in ...
Source: - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
Prof Dame Sarah Gilbert says this will not be the last time a virus threatens our lives and our livelihoodsCoronavirus – latest updatesSee all our coronavirus coverageThe coronavirus pandemic that has so far killed more than 5 million people worldwide is far from over and the next one could be even more lethal, the creator of the Oxford/AstraZeneca vaccine has said.As fears grow over the threat posed by the highly mutated Omicron variant, detected in more than 30 countries,Prof Dame Sarah Gilbert cautioned that while it was increasingly obvious that “this pandemic is not done with us”, the next one could ...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Coronavirus UK news World news Science Infectious diseases Source Type: news
European Journal of Human Genetics, Published online: 06 December 2021; doi:10.1038/s41431-021-01011-830 year experience of index case identification and outcomes of cascade testing in high-risk breast and colorectal cancer predisposition genes
Source: European Journal of Human Genetics - Category: Genetics & Stem Cells Authors: Source Type: research
An Italian healthcare worker was caught trying to fraudulently receive a Covid-19 vaccine in a silicone arm.
Source: Healthcare News - Category: Pharmaceuticals Authors: Tags: Healthcare /healthcare Innovation /innovation Source Type: news
A small study in Boston looked at mixing and matching with the third shot.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Vaccination and Immunization Coronavirus (2019-nCoV) Johnson & Pfizer Inc BioNTech SE Source Type: news
NEW BRUNSWICK, N.J., DECEMBER 5, 2021 – Johnson &Johnson (NYSE: JNJ) (the Company) today announced preliminary results from an independent study, including a subset of participants from the Janssen-sponsored COV2008 study, conducted by Dan Barouch, M.D., Ph.D., et al. of Beth Israel Deaconess Medical Center (BIDMC), which showed that a booster shot of the Johnson &Johnson COVID-19 vaccine (Ad26.COV2.S), administered at six months after a two-dose primary regimen of BNT162b2, increased both antibody and T-cell responses. These results demonstrate the potential benefits of heterologous boosting (mix-and-match)....
Source: Johnson and Johnson - Category: Pharmaceuticals Tags: Innovation Source Type: news
Experts said it is likely that there is already community spread of the variant in the United States.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Coronavirus Omicron Variant Coronavirus (2019-nCoV) Vaccination and Immunization Collins, Francis S Fauci, Anthony S Van Kerkhove, Maria Walensky, Rochelle United States South Africa Disease Rates Source Type: news
CONCLUSION: Overall, pembrolizumab was safe and had limited antitumor activity in these patients. In the advanced, metastatic setting, tumor profiling to understand the mechanisms of resistance to immunotherapy and innovative clinical trials to identify efficacious combination regimens rather than off-label use of pembrolizumab are warranted. DISCUSSION: Germ cell tumors are associated with a diverse histopathology and clinical prognosis. Approximately 20%-30% of patients with metastatic germ cell tumors have disease resistant to standard chemotherapy [1], and 15%-20% of these tumors are incurable with the available t...
Source: The Oncologist - Category: Cancer & Oncology Authors: Tags: Oncologist Source Type: research
AbstractOver the last two decades, molecular-targeted agents have become mainstream treatment for many types of malignancies and have improved the overall survival of patients. However, most patients eventually develop resistance to these targeted therapies. Recently, immunotherapies such as immune checkpoint inhibitors have revolutionized the treatment paradigm for many types of malignancies. Immune checkpoint inhibitors have been approved for treatment of melanoma, non-small cell lung cancer, renal cell carcinoma, head and neck squamous cell carcinoma, Hodgkin ’s lymphoma, bladder cancer and gastric cancer. However...
Source: International Journal of Clinical Oncology - Category: Cancer & Oncology Source Type: research
More News: Cancer | Cancer & Oncology | Cancer Vaccines | Carcinoma | Clinical Trials | Gastric (Stomach) Cancer | Gastroenterology | Immunotherapy | Kidney Cancer | Lung Cancer | Lymphoma | Melanoma | Non-Small Cell Lung Cancer | Renal Cell Carcinoma | Skin Cancer | Surgery | Vaccines