A High-Content Screen for C/EBP α Expression Identifies Novel Therapeutic Agents in Dedifferentiated Liposarcoma

CONCLUSIONS: This high-content screen revealed potential treatments for DDLS. These include irinotecan, which induces apoptosis of DDLS cells in a C/EBPα-dependent, p53-independent manner and should be clinically evaluated in patients with advanced DDLS.PMID:34667024 | DOI:10.1158/1078-0432.CCR-19-2486

Source: Clinical Cancer Research - October 20, 2021 Category: Cancer & Oncology Authors: Christina V Angeles Ana Velez-Rosborough Jordan Rios Bernadette Laxa David Shum Penelope D Ruiz Yawei Shen Irina Ostrovnaya Rodrigo Gularte M érida Benjamin A Nacev Mark A Dickson Hakim Djaballah Tomoyo Okada Samuel Singer Source Type: research