Selective Progesterone Receptor Modulators (SPRMs) and Androgen Receptor Modulators (SARMs) as Treatment for Benign Gynecologic Diseases

In this report we review current evidence for selective progesterone receptor modulators and selective androgen receptor modulators as treatment options for benign gynecologic conditions.
Source: Clinical Obstetrics and Gynecology - Category: OBGYN Tags: Hormone Use in Gynecology Source Type: research

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AbstractStudy questionDoes levonorgestrel-releasing intrauterine device (LNG-IUD) improve post-operative outcomes for endometriosis when compared to other systemic hormonal treatments or no additional treatment?Summary answerWe are uncertain whether LNG-IUD has an impact on dysmenorrhoea when compared to no postoperative treatment or post-operative GnRH agonists (GnRH-a).What is known alreadyEndometriosis is a condition characterised by the presence of ectopic deposits of endometrial-like tissue outside the uterus, usually in the pelvis; inducing a chronic inflammatory response which can lead to pelvic pain and infertility...
Source: Human Reproduction - Category: Reproduction Medicine Source Type: research
Endometriosis is a relatively common condition in which endometrial tissue is established in locations outside the uterus where, like the eutopic endometrium, it responds to hormonal stimuli and develops internal bleeding, inflammation, and fibrosis. These changes are associated with chronic and often debilitating cyclic pain and infertility. The pathogenesis of endometriosis is multifactorial, and several theories have been proposed to explain it. These include retrograde menstruation, celomic metaplasia, embryologic rests, and lymphovascular spread. Hormones, immunologic status, and genetic factors may also play a role. ...
Source: Advances in Anatomic Pathology - Category: Pathology Tags: Review Articles Source Type: research
ConclusionTraditionally only pathologies of the uterus and ovaries are assessed during a routine pelvic ultrasound. Here we demonstrate that the routine ultrasound examination can easily be extended beyond the uterus and ovaries into the posterior and anterior pelvic compartments to evaluate structural mobility and to look for deep infiltrating endometriotic nodules, so women suffering from deep infiltrating endometriosis can benefit from a pre-operative diagnosis and subsequently a single, well-planned procedure in the hands of a well-prepared team.
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
When my first period came at age 13, it involved blood clots and extreme pain. I didn’t know what to expect or what was considered “normal,” but thankfully, my mother did. She recognized that my symptoms were unusual and immediately took me to see my pediatrician. I was first prescribed birth control pills, which seemed to help initially, but when my period remained heavy and painful, I was put on a different birth control pill that enabled me to have my period only four times a year. I thought my situation was normal – albeit uncomfortable and inconvenient. No one ever suggested that painful period...
Source: Thrive, Children's Hospital Boston - Category: Pediatrics Authors: Tags: Our Patients’ Stories Teen Health endometriosis Marc Laufer Source Type: news
Andrea Syrtash was first hospitalized at the age of 14 for painful and heavy menstrual cycles due to endometriosis. She had no idea her condition would affect her fertility â€• and even if she had known, she may not have thought to address it without guidance from her doctors. After six years of trying to conceive, Syrtash, who’s now in her 40s and works as a relationship and dating expert, recently founded pregnantish, a website for singles, couples and LGBTQ people who are trying to conceive.  “When you’re a teenager, it’s not on your mind,” she said. Had she known, “I migh...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news
Abstract Endometriosis is a chronic disease of women during their reproductive age. The most typical symptoms are dysmenorrhoea, dyspareunia, dysuria, cyclical and acyclical pelvic pain, bleeding disorders and infertility. These symptoms lead to significant impairment of the quality of life and economic burden. The prevalence is estimated to be 2-20 % of all women in this age and due to this fact, it is one of the most frequently benign gynecological diseases. Not all women suffer from severe symptoms, but more than 50 % require ongoing treatment. Beside the severe physical impairment due to the...
Source: Schmerz - Category: Anesthesiology Authors: Tags: Schmerz Source Type: research
Despite what a carefree tampon commercial would have you believe, that time of the month can be uncomfortable, varied and complex. No two periods look the same: Some women experience excruciating symptoms each time. Others may skip months entirely. And did you know that men can also have a physical reaction to a woman’s monthly cycle? Basically, there’s more to a period than what you hear in pop culture. And it will serve everyone better to be more informed about the process and armed with the facts. Below are a few things everyone should know about that oh-so-wonderful time of the month: 1. The ...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news
Endometriosis is a chronic inflammatory disease characterized by the growth of endometrial glands and stroma outside of the uterus. The disease affects approximately 10–15% of women of reproductive age and presents with clinical symptoms of pelvic pain and infertility. Changes in the leukocyte populations within the ectopic tissue and eutopic endometrium have been reported, and data suggest these alterations contribute to the pathology and symptoms of the disease. In this review, we discussed differences when comparing uterine NK cells and regulatory T cells within the eutopic endometrium between patients with endome...
Source: American Journal of Reproductive Immunology - Category: Allergy & Immunology Authors: Tags: Review Article Source Type: research
The post Endometriosis – Hope is at Hand appeared first on Hysterectomy Association. ‘Historically, the symptoms of inexplicable chronic pelvic pain have often been attributed to imagined madness, female weakness, promiscuity or hysteria’ Wikipedia on Endometriosis. Fortunately, the tide has turned on this outmoded way of thinking! Modern medicine recognises the painful truth about endometriosis and uterine fibroids to such an extent that Covance, the clinical research unit in Leeds, has an upcoming study which could provide hope for women suffering from these aggressive and often debilitating conditions....
Source: The Hysterectomy Association - Category: OBGYN Authors: Tags: Research clinical trials endometriosis fibroids Source Type: news
Endometriosis is a benign inflammatory disease defined by the presence of endometrial glands and stroma in areas outside the uterus. It is estimated to affect 5%–15% of women of reproductive age and is even more prevalent among women with chronic pelvic pain and infertility. Endometriotic implants may be located anywhere within the pelvis, including the ovaries, ovarian fossa, pelvic peritoneum, rectovaginal septum, uterosacral ligaments, and cul-de sac. In some cases, ovarian endometriotic cysts (endometriomas) may be observed by ultrasound imaging.
Source: Fertility and Sterility - Category: Reproduction Medicine Authors: Tags: Inklings Source Type: research
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