Viruses, Vol. 13, Pages 2123: Evaluation of Antiviral Activity of Cyclic Ketones against Mayaro Virus

In this study, the antiviral activity of a series of synthetic cyclic ketones were evaluated for the first time against MAYV. Twenty-four compounds were screened in a cell viability assay, and eight were selected for further evaluation. Effective concentration (EC50) and selectivity index (SI) were calculated and compound 9-(5-(4-chlorophenyl]furan-2-yl)-3,6-dimethyl-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2))-dione (9) (EC50 = 21.5 µmol·L–1, SI = 15.8) was selected for mechanism of action assays. The substance was able to reduce viral activity by approximately 70% in both pre-treatment and post-treatment assays.

Source: Viruses - October 21, 2021 Category: Virology Authors: Luciana S. Fernandes Milene L. da da Silva Roberto S. Dias Marcel S. da S. da S. Lucindo Ítalo E. P. da da Silva Cynthia C. Silva R óbson R. Teixeira S érgio O. de de Paula Tags: Communication Source Type: research