Bipolar disorder in the postpartum period: the impact of a prenatal mood episode on maternal improvement at postpartum discharge after joint inpatient hospitalization - Lasica PA, Glangeaud-Freudenthal NMC, Falissard B, Sutter-Dallay AL, Gressier F.

Bipolar disorder (BD) is linked to a high risk of relapse in the year postpartum. The aim of this study was to search for an association of a mood episode during pregnancy with a lack of maternal improvement after a post-partum episode requiring joint hosp...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Infants and Children Source Type: news

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Although it has been suggested that pregnancy may influence the course of bipolar disorder (BD), studies show contradictory results. Until now, no studies included a finegrained validated method to report mood...
Source: International Journal of Bipolar Disorders - Category: Psychiatry Authors: Tags: Research Source Type: research
In conclusion, prenatal exposure to VPA causes histopathological alterations in the offspring of mice in testicular development, from the embryonic stage to 6 weeks postnatal.PMID:34664708 | DOI:10.14670/HH-18-380
Source: Histology and Histopathology - Category: Cytology Authors: Source Type: research
CASE: As part of a multidisciplinary adoption support clinic, Erin, a 5-year-old girl, adopted approximately 6 months before the clinic visit, presents for postadoption evaluation. Erin was born at full term. Her birth history was significant for reported maternal treatment for liver failure during pregnancy. Her previous medical history included hospitalization for a viral illness at age 2 months, recurrent ear infections, and a fractured forearm. Family history was significant for a maternal history of bipolar disorder, depression, anxiety, borderline personality disorder, and concern for substance abuse; a paternal ...
Source: Journal of Developmental and Behavioral Pediatrics - Category: Child Development Tags: Challenging Case Source Type: research
We present a case with a past medical history of bipolar disorder treated with lithium for almost 20 years. His family history was significant for HTN. The patient was diagnosed with renal insufficiency of unknown causes, for which he underwent renal biopsy. The renal biopsy showed a typical lithium-induced tubulointerstitial nephritis and a coincidental finding of IgA-N. We suspect a high activity of SLC-T seen in IgA-N, and the adverse effects of lithium on SLC-T activity might cause reduction of urinary lithium clearance and accumulation of lithium in distal renal tubular cells, contributing to nephrotoxicity. There is ...
Source: Case Reports in Nephrology and Dialysis - Category: Urology & Nephrology Source Type: research
Conclusions: In breastfeed infant no sustained accumulation of lithium and no adverse effects on development or growth were observed.
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Hypofunction of glutamatergic signaling is causally linked to neurodevelopmental disorders, including psychotic disorders like schizophrenia and bipolar disorder. Kynurenic acid (KYNA) has been found to be elevated in postmortem brain tissue and cerebrospinal fluid of patients with psychotic illnesses and may be involved in the hypoglutamatergia and cognitive dysfunction experienced by these patients. As insults during the prenatal period are hypothesized to be linked to the pathophysiology of psychotic disorders, we presently utilized the embryonic kynurenine (EKyn) paradigm to induce a prenatal hit. Pregnant Wistar dams ...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
CONCLUSION: Risk and benefits of lithium use during the peripartum should be carefully considered, if possible prior to conception. Close monitoring of maternal lithium levels and renal function is necessary due to significant fluctuations during peripartum.PMID:34523708
Source: Tijdschrift voor Psychiatrie - Category: Psychiatry Authors: Source Type: research
CONCLUSION: Patients seen for guidance by the POP-collaboration at the LUMC are a vulnerable patient population with frequently complex psychopathology, and need personalized psychoeducation, supervision and treatment.PMID:34523704
Source: Tijdschrift voor Psychiatrie - Category: Psychiatry Authors: Source Type: research
CONCLUSION: Risk and benefits of lithium use during the peripartum should be carefully considered, if possible prior to conception. Close monitoring of maternal lithium levels and renal function is necessary due to significant fluctuations during peripartum.PMID:34523708
Source: Tijdschrift voor Psychiatrie - Category: Psychiatry Authors: Source Type: research
CONCLUSION: Patients seen for guidance by the POP-collaboration at the LUMC are a vulnerable patient population with frequently complex psychopathology, and need personalized psychoeducation, supervision and treatment.PMID:34523704
Source: Tijdschrift voor Psychiatrie - Category: Psychiatry Authors: Source Type: research
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