Niclosamide for Covid-19: bridging the gap

CONCLUSIONS: NCL has anti-inflammatory and immune regulatory effects by modulating the release of pro-inflammatory cytokines, inhibition of NF-κB /NLRP3 inflammasome and mTOR signaling pathway. NCL has an anti-SARS-CoV-2 effect via interruption of viral life-cycle and/or induction of cytopathic effect. Prospective clinical studies and clinical trials are mandatory to confirm the potential role of NCL in patients with Covid-19 concerning the severity and clinical outcomes.PMID:34664162 | DOI:10.1007/s11033-021-06770-7
Source: Molecular Medicine - Category: Molecular Biology Authors: Source Type: research