Developing and Validating an Effective Pediatric and Adolescent HIV Testing Eligibility Screening Tool for High-Volume Entry Points in Uganda

Conclusions: This HIV screening tool has high sensitivity and reasonable specificity, increasing testing efficiency and yield for children and adolescents.
Source: JAIDS Journal of Acquired Immune Deficiency Syndromes - Category: Infectious Diseases Tags: Implementation Science Source Type: research

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IJERPH, Vol. 18, Pages 12827: Factors Associated with Unfavourable Treatment Outcomes in Patients with Tuberculosis: A 16-Year Cohort Study (2005–2020), Republic of Karakalpakstan, Uzbekistan International Journal of Environmental Research and Public Health doi: 10.3390/ijerph182312827 Authors: Jamshid Gadoev Damin Asadov Anthony D. Harries Ajay M. V. Kumar Martin Johan Boeree Araksya Hovhannesyan Lianne Kuppens Askar Yedilbayev Oleksander Korotych Atadjan Hamraev Kallibek Kudaybergenov Barno Abdusamatova Bakhtinur Khudanov Masoud Dara Tuberculosis (TB) remains a public health burden...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
In conclusion, our results demonstrated that hsa_circ_0045474 down-regulation induced macrophage autophagy in tuberculosis via miR-582-5p/ TNKS2 axis, implying a novel strategy to treat the occurrence of active pulmonary tuberculosis caused by immune escape of M. tuberculosis.PMID:34861798 | DOI:10.1177/17534259211064285
Source: Innate Immunity - Category: Allergy & Immunology Authors: Source Type: research
In conclusion, our results suggest that ILC2s may promote Th2-type immune response in different stages of TB via the Notch-GATA3 pathway.PMID:34862127 | DOI:10.1016/j.intimp.2021.108330
Source: International Immunopharmacology - Category: Allergy & Immunology Authors: Source Type: research
ConclusionsTrauma and pulmonary tuberculosis complicated with adrenal tuberculosis induced the adrenal crisis, which eventually lead to severe cerebral edema and hernia, and finally death from respiratory and circulatory failure. This autopsy and histopathologic examination suggested a possible pathophysiologic mechanism of sudden death due to diluted hyponatremia after trauma surgery.
Source: European Journal of Medical Research - Category: Research Source Type: research
ConclusionsThis qualitative analysis highlights ways in which insights developed together with patients and healthcare workers might inform approaches towards improved recruitment into trials, with the overall objective of delivering evidence for better treatments.
Source: Trials - Category: Research Source Type: clinical trials
There was a complete lack of information about the treatment outcomes of rifampicin/multidrug resistant (RR/MDR) childhood TB patients (age  ≤ 14 years) from Pakistan, an MDR-TB 5th high burden country. Therefo...
Source: BMC Infectious Diseases - Category: Infectious Diseases Authors: Tags: Research Source Type: research
Yohei Sasakawa – WHO Goodwill Ambassador for Leprosy Elimination and Chairman of Sasakawa Health Foundation speaking at the 3rd of the “Don’t Forget Leprosy” webinar series organized by Sasakawa Health Foundation on Dec 2. Credit: Stella PaulBy Stella PaulHyderabad, Dec 3 2021 (IPS) As 2021 nears its end, public health systems worldwide remain severely strained by COVID 19, which is showing no sign of ending. But even as countries battle to control the deadly pandemic, they must also maintain the progress made against other diseases, including leprosy, global leprosy experts and advocates have urged...
Source: IPS Inter Press Service - Health - Category: International Medicine & Public Health Authors: Tags: COVID-19 Editors' Choice Featured Global Health Human Rights Humanitarian Emergencies Inequity TerraViva United Nations #Sasakawa IPS UN Bureau leprosy Source Type: news
SPRING HOUSE, PENNSYLVANIA, December 3, 2021 – The Janssen Pharmaceutical Companies of Johnson &Johnson today announced new TREMFYA® (guselkumab) efficacy and safety data from the Phase 3b COSMOS trial published in Annals of the Rheumatic Diseases (ARD), evaluating this selective interleukin (IL)-23 inhibitor in adults with active psoriatic arthritis (PsA) who demonstrated inadequate efficacy or intolerance to tumor necrosis factor inhibition (TNFi).1 Results showed significantly higher proportions of patients treated with TREMFYA had improvement in joint signs and symptoms and complete skin clearance versus ...
Source: Johnson and Johnson - Category: Pharmaceuticals Tags: Innovation Source Type: news
Am J Respir Crit Care Med. 2021 Dec 3. doi: 10.1164/rccm.202105-1306IM. Online ahead of print.NO ABSTRACTPMID:34861138 | DOI:10.1164/rccm.202105-1306IM
Source: Am J Respir Crit Car... - Category: Intensive Care Authors: Source Type: research
CONCLUSIONS: Immunotherapy is relatively safe for lung cancer patients complicated with previously treated latent TB, and the efficacy of immunotherapy in this specified population is not inferior to that in lung cancer patients without TB infection. TB screening before anti-PD-1/PD-L1 immunotherapy is strongly recommended, and irAEs should be monitored more cautiously in lung cancer patients with active TB infection.PMID:34858782 | PMC:PMC8577979 | DOI:10.21037/tlcr-21-524
Source: Cell Research - Category: Cytology Authors: Source Type: research
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