Gene silencing medicine transforms crippling pain

The NHS is set to fund innovative therapy that patients say has given them their lives back.
Source: BBC News | Health | UK Edition - Category: Consumer Health News Source Type: news

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SPRING HOUSE, PENNSYLVANIA, December 3, 2021 – The Janssen Pharmaceutical Companies of Johnson &Johnson today announced new TREMFYA® (guselkumab) efficacy and safety data from the Phase 3b COSMOS trial published in Annals of the Rheumatic Diseases (ARD), evaluating this selective interleukin (IL)-23 inhibitor in adults with active psoriatic arthritis (PsA) who demonstrated inadequate efficacy or intolerance to tumor necrosis factor inhibition (TNFi).1 Results showed significantly higher proportions of patients treated with TREMFYA had improvement in joint signs and symptoms and complete skin clearance versus ...
Source: Johnson and Johnson - Category: Pharmaceuticals Tags: Innovation Source Type: news
In conclusion, this study suggested that Bel might serve as a drug for nociception management by inhibiting CXCR3 and upregulating GABAA receptor. This study may offer novel insights into the field of neuropathic pain relief.PMID:34860610 | DOI:10.1139/cjpp-2021-0636
Source: Canadian Journal of Physiology and Pharmacology - Category: Drugs & Pharmacology Authors: Source Type: research
Conclusion: Red cell distribution width has a poor diagnostic value for chronicity in nonspecific low back pain.PMID:34856812 | DOI:10.2217/bmm-2021-0431
Source: Future Medicine: Biomarkers in Medicine - Category: Internal Medicine Authors: Source Type: research
The use of constant pain and night pain as clinical markers for predicting the presence of underlying pathology in painful adolescent idiopathic scoliosis (AIS) patients has been questioned. Pain intensity has been recognized as an important domain in pain assessment. The numerical rating scale (NRS) is one of the most commonly validated tools to assess pain intensity in children above 8 years of age. The aim of this study was to assess the NRS as a predictor of underlying pathologies found by MRI in painful AIS patients. A cross-sectional study comprising of all AIS patients with back pain lasting>4 weeks...
Source: Journal of Pediatric Orthopaedics B - Category: Orthopaedics Tags: Spine Source Type: research
The prevalence of low-back pain (LBP) in adolescents ranges from 7 to 72%. We aimed to define the radiologic characteristics of the lumbar spine in children and adolescents with LBP with/without leg pain. Two hundred and fourteen children and adolescents, who were born between 2001 and 2009 and had lumbar spine MRI for LBP with/without leg pain, were evaluated in terms of intervertebral disc degeneration (IVDD), end-plates and paraspinal muscle changes on lumbar spine MRIs. Severe IVDD was detected at all lumbar levels except for L2–L3. Modic changes were present in 4.2% of the patients. Modic changes were more commo...
Source: Journal of Pediatric Orthopaedics B - Category: Orthopaedics Tags: Spine Source Type: research
Conclusion: CSE analgesia did not affect the duration of labour, mode of delivery with minimal fetomaternal adverse effects and provides rapid onset of pain relief . CSE analgesia can be considered for safe and effective labour analgesia.
Source: Annals of African Medicine - Category: African Health Authors: Source Type: research
ConclusionsPreference heterogeneity across respondents indicates a need for a personalized approach to offering treatment options. Symptom improvement, cost, physical dependence and route of administration might be important to different patients.
Source: European Journal of Pain - Category: Anesthesiology Authors: Tags: ORIGINAL ARTICLE Source Type: research
CONCLUSIONS: Inconclusive evidence exists for the use of smartphone applications for the self-management of low back pain. Further research is needed.Implications for RehabilitationSmartphone apps have the potential to improve outcomes for people with LBP aligned with current self-management guidelines.There is a paucity of literature exploring smartphone apps for LBP self-management and current evidence is inconclusive for smartphone app use without supported care.Commercially available smartphone apps are not well regulated for content or alignment with evidence-based guidelines and recommendations.Further evaluation of ...
Source: Disability and Rehabilitation - Category: Rehabilitation Authors: Source Type: research
In conclusion, according to the above analyses, the interaction between DNP and extracellular signal-regulated kinase signal transduction pathway is one of the key factors of pathogenesis.PMID:34853620 | PMC:PMC8629657 | DOI:10.1155/2021/3470950
Source: Disease Markers - Category: Laboratory Medicine Authors: Source Type: research
CONCLUSION: Qualitative research will continue to be an important component in future research on the use of EAW training as part of the rehabilitation process. Increasing understanding of the participants experience with this novel therapeutic modality and technology will be fundamental to improve its implementation in clinical practice.PMID:34855574 | DOI:10.1080/10790268.2021.1983314
Source: Journal of Spinal Cord Medicine - Category: Orthopaedics Authors: Source Type: research
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