Population pharmacokinetics of intravenous and oral ciprofloxacin in children to optimize dosing regimens

ConclusionThe recommended IV dose of 10  mg/kg q8h, not exceeding 400 mg q8h, would achieve AUC0-24  h to successfully treat bacteria with MICs  ≤ 0.25 (e.g. Salmonella, Escherichia coli, Proteus, Haemophilus, Enterobacter, and Klebsiella). A dose increase to 600 mg q8h in children >  40 kg and to 15 mg/kg q8h (max 400 mg q8h, max 600 mg q8h if augmented renal clearance, i.e., eGFR >  200 mL/min/1.73 m2) in children  
Source: European Journal of Clinical Pharmacology - Category: Drugs & Pharmacology Source Type: research

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Bioorg Chem. 2021 Nov 25;119:105517. doi: 10.1016/j.bioorg.2021.105517. Online ahead of print.ABSTRACTSulfahydantoins are five-membered rings found in the structure of chemicals that exhibit antibacterial, anti-inflammatory, and anticonvulsant properties. They also activate serine protease enzymes that catalyze the hydrolysis of peptide bonds. Five 3-imino sulfahydantoin compounds were synthesized by using Strecker synthesis reaction with minor modifications. We used reflux of various aldehydes with excess sulfamide in 85% methanol in the presence of sodium cyanide. The spectroscopic properties of these compounds were stud...
Source: Bioorganic Chemistry - Category: Chemistry Authors: Source Type: research
Bioorg Chem. 2021 Nov 22:105507. doi: 10.1016/j.bioorg.2021.105507. Online ahead of print.ABSTRACTPreparation and comprehensive characterization of three Schiff base ligands; with trimethoxy substitution (1E,1'E)-N,N'-(naphthalene-1,5-diyl)bis(1-(3,4,5-trimethoxyphenyl)methanimine, 1, with ortho-hydroxy substitution 6,6'-((1E,1'E)-(naphthalene-1,5-diylbis(azaneylylidene))bis(methaneylylidene))bis(2-methoxyphenol), 2 and 3,4-bis(((E)-2-hydroxy-3-methoxy benzylidene)amino)benzoicacid, 3 and their Ni(II), Cu(II), Co(II), Zn(II), Fe(II), Mn(II) complexes have been reported. Their spectral properties were studied in solution an...
Source: Bioorganic Chemistry - Category: Chemistry Authors: Source Type: research
In this study, sixteen esters ( 1 - 16 ) were synthesized from ursolic acid using DIC/DMAP and characterized by infrared and nuclear magnetic resonance ( 1 H- and 13 C-NMR) spectrometry. All ursolic acid esters were evaluated against the bacteria Bacillus cereus , Staphylococcus aureus , Escherichia coli , Salmonella typhimurium , and the yeast Candida albicans . Six compounds are herein described for the first time ( 3 , 9 , 11 , 13 , 14 and 16 ) with reaction yields up to 91.6%. Compounds 11 (3 β- (3,4-dimethoxybenzoyl) ursolic acid) and 15 (3 β -nicotinoyl ursolic acid) displayed promising antifungal activity,...
Source: Chemistry and Biodiversity - Category: Biochemistry Authors: Source Type: research
CONCLUSION: The ethanolic extracts of Artemisia absinthium leaves and Citrus paradisi peels can be used against liver cancer because of their antioxidant, antibacterial, and anticancer activities.PMID:34755263 | DOI:10.1007/s11033-021-06777-0
Source: Molecular Biology Reports - Category: Molecular Biology Authors: Source Type: research
This study provides an alternative utilization of R. gallica var. aegyptiaca leaves as a readily accessible source of natural antioxidants and antimicrobials in the food and pharmaceutical industries.
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
ConclusionThe recommended IV dose of 10  mg/kg q8h, not exceeding 400 mg q8h, would achieve AUC0-24  h to successfully treat bacteria with MICs  ≤ 0.25 (e.g. Salmonella, Escherichia coli, Proteus, Haemophilus, Enterobacter, and Klebsiella). A dose increase to 600 mg q8h in children >  40 kg and to 15 mg/kg q8h (max 400 mg q8h, max 600 mg q8h if augmented renal clearance, i.e., eGFR >  200 mL/min/1.73 m2) in children  
Source: European Journal of Clinical Pharmacology - Category: Drugs & Pharmacology Source Type: research
Int J Biol Macromol. 2021 Oct 21:S0141-8130(21)02276-5. doi: 10.1016/j.ijbiomac.2021.10.118. Online ahead of print.ABSTRACTIn this work, the feasibility of antibacterial biopolymeric films containing carvacrol (CRV) and a nisin commercial formulation (Nis) for potential food packaging applications was investigated. As polymer matrix, a commercial biodegradable polymer formulation of Mater-Bi (MB) was chosen due to its significant food packaging applications. CRV and Nis were chosen due to their well-established antibacterial properties and their potential synergistic effect. MB/CRV, MB/Nis, and MB/CRV/Nis systems were prod...
Source: International Journal of Biological Macromolecules - Category: Biochemistry Authors: Source Type: research
J Microbiol Biotechnol. 2021 Oct 15;31. doi: 10.4014/jmb.2109.09038. Online ahead of print.ABSTRACTFood safety is the most important global health issue due to foodborne pathogens after consumption of contaminated food. Foodborne bacteria such as Escherichia coli, Salmonella enterica, Staphylococcus aureus, Campylobacter spp., Bacillus cereus, Vibrio spp., Yersinia enterocolitica and Clostridium perfringens are leading causes of the majority of foodborne illnesses and deaths. These foodborne pathogens often come from the livestock feces, thus, we analyzed fecal microbial communities of three different livestock species to ...
Source: Journal of Microbiology and Biotechnology - Category: Biotechnology Authors: Source Type: research
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