Ability to detect potentially inappropriate prescribing in older patients: comparative analysis between PIM-Check and STOPP/STARTv2

ConclusionsBy using PIM-Check in geriatric settings, some PIP will not be detected. It is considered as a limitation for this tool in this frail population but brings a certain complementarity in other areas of therapy not covered by STOPP/START.
Source: European Journal of Clinical Pharmacology - Category: Drugs & Pharmacology Source Type: research

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Conclusion: Medical students lack significant knowledge and training about dementia. Patient contact and practical training for basic assessment and care of dementia needs to be incorporated in the current academic curriculum. Dedicated sensitization sessions on dementia care can help improve the gap. Practical exposure to management of patients with dementia would be required to enhance the comfort level and attitude of students towards dementia.
Source: Annals of Indian Academy of Neurology - Category: Neurology Authors: Source Type: research
Curr Alzheimer Res. 2021 Dec 2. doi: 10.2174/1567205018666211202143935. Online ahead of print.ABSTRACTAlzheimer's disease is a progressive and deadly neurodegenerative disorder, and one of the most common causes of dementia in the world. Current, insufficiently sensitive and specific methods of early diagnosis and monitoring of this disease prompt a search for new tools. Numerous literature data indicate that the pathogenesis of Alzheimer's disease (AD) is not limited to the neuronal compartment, but involves various immunological mechanisms. Neuroinflammation has been recognized as a very important process in AD pathology...
Source: Current Alzheimer Research - Category: Neurology Authors: Source Type: research
Conclusion: The present study highlights potential benefits of community-based arts activities in enabling caregiving to be a more positive experience for care partners.Supplemental data for this article is available online at http://dx.doi.org/10.1080/13607863.2021.2008306'I kept blaming myself for not spending enough time with him. Communication with him is different now. Watching him on the stage, he is happy and with a purpose'. (Gary, male).PMID:34856835 | DOI:10.1080/13607863.2021.2008306
Source: Aging and Mental Health - Category: Geriatrics Authors: Source Type: research
EMBO Mol Med. 2021 Dec 3:e14408. doi: 10.15252/emmm.202114408. Online ahead of print.ABSTRACTNeurodegenerative disorders such as Alzheimer's disease (AD) represent a mounting public health challenge. As these diseases are difficult to diagnose clinically, biomarkers of underlying pathophysiology are playing an ever-increasing role in research, clinical trials, and in the clinical work-up of patients. Though cerebrospinal fluid (CSF) and positron emission tomography (PET)-based measures are available, their use is not widespread due to limitations, including high costs and perceived invasiveness. As a result of rapid advanc...
Source: Molecular Medicine - Category: Molecular Biology Authors: Source Type: research
Curr Alzheimer Res. 2021 Dec 2. doi: 10.2174/1567205018666211202143935. Online ahead of print.ABSTRACTAlzheimer's disease is a progressive and deadly neurodegenerative disorder, and one of the most common causes of dementia in the world. Current, insufficiently sensitive and specific methods of early diagnosis and monitoring of this disease prompt a search for new tools. Numerous literature data indicate that the pathogenesis of Alzheimer's disease (AD) is not limited to the neuronal compartment, but involves various immunological mechanisms. Neuroinflammation has been recognized as a very important process in AD pathology...
Source: Current Alzheimer Research - Category: Neurology Authors: Source Type: research
Conclusion: The present study highlights potential benefits of community-based arts activities in enabling caregiving to be a more positive experience for care partners.Supplemental data for this article is available online at http://dx.doi.org/10.1080/13607863.2021.2008306'I kept blaming myself for not spending enough time with him. Communication with him is different now. Watching him on the stage, he is happy and with a purpose'. (Gary, male).PMID:34856835 | DOI:10.1080/13607863.2021.2008306
Source: Aging and Mental Health - Category: Geriatrics Authors: Source Type: research
CONCLUSIONS: Our findings suggest the implementation of signs with positive contrast polarity to ensure faster reactions. In addition, certain color combinations may enhance accuracy, particularly in patients with ADD.PMID:34861672 | DOI:10.1097/WAD.0000000000000478
Source: Alzheimer Disease and Associated Disorders - Category: Psychiatry Authors: Source Type: research
DISCUSSION: Higher RHR is associated with increased risk for dementia and faster cognitive decline independent of CVDs in a general population of elderly people.PMID:34859936 | DOI:10.1002/alz.12495
Source: The Journal of Alzheimers Association - Category: Psychiatry Authors: Source Type: research
IT IS common for sleep habits to change as you advance in age, but certain sleep habits in earlier life could increase your risk of developing Alzheimer's in later life.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
We examined the ability of plasma hyperphosphorylated tau (p-tau)181 to detect cognitive impairment due to Alzheimer's disease (AD) independently and in combination with plasma total tau (t-tau) and neurofilament light (NfL).METHODS: Plasma samples were analyzed using the Simoa platform for 235 participants with normal cognition (NC), 181 with mild cognitive impairment due to AD (MCI), and 153 with AD dementia. Statistical approaches included multinomial regression and Gaussian graphical models (GGMs) to assess a network of plasma biomarkers, neuropsychological tests, and demographic variables.RESULTS: Plasma p-tau181 disc...
Source: The Journal of Alzheimers Association - Category: Psychiatry Authors: Source Type: research
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