LncRNA NEAT1 Promotes Proliferation, Migration and Invasion via Regulating miR-296-5p/CNN2 Axis in Hepatocellular Carcinoma Cells Retraction

Source: OncoTargets and Therapy - Category: Cancer & Oncology Tags: OncoTargets and Therapy Source Type: research

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Source: OncoTargets and Therapy - Category: Cancer & Oncology Tags: OncoTargets and Therapy Source Type: research
Source: Cancer Management and Research - Category: Cancer & Oncology Tags: Cancer Management and Research Source Type: research
Source: Infection and Drug Resistance - Category: Infectious Diseases Tags: Infection and Drug Resistance Source Type: research
Free Radic Res. 2021 Dec 6:1-52. doi: 10.1080/10715762.2021.2013480. Online ahead of print.ABSTRACTUndesired toxicity and emergence of multidrug resistance (MDR) are the major impediments for the successful application of organotin-based compounds against cancer. Since oxalyl-bis(N-phenyl)hydroxamic acid (OBPHA) exerts significant efficacy against cancer, we believe that derivatives of OBPHA including organotin molecule can show a promising effect against cancer. Herein, we have selected three previously characterized OBPHA derivatives viz., succinyl-bis(N-phenyl)hydroxamic acid (SBPHA), diphenyl-tin succinyl-bis(N-phenyl)...
Source: Free Radical Research - Category: Research Authors: Source Type: research
Oncol Lett. 2022 Jan;23(1):22. doi: 10.3892/ol.2021.13140. Epub 2021 Nov 17.ABSTRACTFrequent recurrence is a major issue in liver cancer and histological heterogeneity frequently occurs in this cancer type. However, it has remained elusive whether such cancers are multicentric or monoclonal. To elucidate the clonal evolution of hepatocellular carcinoma (HCC) recurrence and combined hepatocellular-cholangiocarcinoma (cHCC-CCA) development, the somatic mutation frequency and signatures in a patient with triple occurrence of liver cancer every three years were examined, with samples designated as #1HCC, #2HCC and #3cHCC-CCA, ...
Source: Oncology Letters - Category: Cancer & Oncology Authors: Source Type: research
Front Cell Dev Biol. 2021 Nov 12;9:715905. doi: 10.3389/fcell.2021.715905. eCollection 2021.ABSTRACTB7 family proteins serve as checkpoint molecules that protect tumors from T cell mediated lysis. Tryptophan degrading enzymes indoleamine 2,3 dioxygenase (IDO) and tryptophan 2,3 dioxygenase (TDO) also induce T cell immune tolerance. However, little is known about the relative contribution of B7 molecules, tryptophan degrading enzymes, as well as the impact of tumor and stromal cell interactions to the development of immunosuppressive tumor microenvironment. To investigate such interactions, we used a tripartite model of hum...
Source: Cancer Control - Category: Cancer & Oncology Authors: Source Type: research
J Invest Surg. 2021 Dec 5:1-7. doi: 10.1080/08941939.2021.2012615. Online ahead of print.ABSTRACTBackground/Aim: Alpha-fetoprotein (AFP) had been used as a prognostic factor in hepatocellular carcinoma but it was unknown what level of AFP could predict the survival of patients with ruptured hepatocellular carcinoma (rHCC) after resection. This retrospective study was to identify the best cutoff value of AFP for this prediction.Methods: Data of patients having hepatectomy for rHCC from 1989 to 2015 were reviewed. The receiver operating characteristic curve and Youden's index were used to identify the cutoff value of AFP aff...
Source: Journal of Investigative Surgery - Category: Surgery Authors: Source Type: research
Conclusions: The availability of multiple MTAs had steadily improved the prognosis of patients with advanced HCC patients, particularly advanced-stage HCC patients.Liver Cancer
Source: Liver Cancer - Category: Cancer & Oncology Source Type: research
Journal of Natural ProductsDOI: 10.1021/acs.jnatprod.1c00963
Source: Journal of Natural Products - Category: Biochemistry Authors: Source Type: research
Contributor : Susanta RoychoudhurySeries Type : Expression profiling by arrayOrganism : Homo sapiensCdc20 acts as a regulatory protein interacting with many other proteins at multiple points in the cell cycle. Here we tried to explore the novel transcription regulatory function of Cdc20 by means of altering Cdc20 level in HepG2 cells. We transiently over expressed Flag tagged Cdc20 (F) and siRNA mediated knocked down Cdc20(S) in HepG2 cell line and performed whole genome microarray analysis using illumina BeadChip Array. Significantly altered genes were subjected to the analysed by Ingenuity pathway analysis software (Buil...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
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