Gene sequencing in ovarian cancer: continually moving targets

BJOG. 2021 Oct 19. doi: 10.1111/1471-0528.16978. Online ahead of print.ABSTRACTRoutine BRCA1/2 sequencing in ovarian cancer patients has come a long way since referrals to clinical genetics for sequencing were based upon the often imperfect assessment of family history in a gynaecological surgery or medical oncology clinic and the subsequent determination that the risk of an underlying genetic abnormality was above a particular threshold (often 10%).PMID:34665910 | DOI:10.1111/1471-0528.16978
Source: BJOG : An International Journal of Obstetrics and Gynaecology - Category: OBGYN Authors: Source Type: research

Related Links:

Source: OncoTargets and Therapy - Category: Cancer & Oncology Tags: OncoTargets and Therapy Source Type: research
Clin Cancer Res. 2021 Nov 29:clincanres.1186.2021. doi: 10.1158/1078-0432.CCR-21-1186. Online ahead of print.ABSTRACTBACKGROUND: Phase I results of this phase I/II study showed that pamiparib 60 mg BID had antitumor activity and an acceptable safety profile in Chinese patients with advanced cancer, including epithelial ovarian cancer (OC).METHODS: This open-label phase II study was conducted in China and enrolled adult ({greater than or equal to}18 years) patients with platinum-sensitive OC (PSOC, disease progression occurring {greater than or equal to}6 months after last platinum treatment) or platinum-resistant OC (PROC,...
Source: Clinical Cancer Research - Category: Cancer & Oncology Authors: Source Type: research
CONCLUSION: This study suggests that resistance training improves upon desirable changes in adaptive immune cell responses in ovarian cancer survivors by maintaining skeletal muscle mass while developing strength and endurance.PMID:34844392 | DOI:10.5213/inj.2142346.173
Source: International Neurourology Journal - Category: Urology & Nephrology Authors: Source Type: research
Clin Ther. 2021 Nov 26:S0149-2918(21)00452-5. doi: 10.1016/j.clinthera.2021.10.014. Online ahead of print.ABSTRACTPURPOSE: Inoperable malignant intestinal obstruction (IMIO) is a severe complication in patients with cancer, usually gastrointestinal or gynecologic in origin. For patients with IMIO, there is a need to relieve symptoms and limit nasogastric tube (NGT) use. Previous studies have suggested the efficacy of somatostatin analogues in relieving obstruction-related symptoms, such as nausea, vomiting, and pain. The purpose of this study was to assess the efficacy of lanreotide autogel 120 mg (LAN 120 mg) in the manag...
Source: Clinical Therapeutics - Category: Drugs & Pharmacology Authors: Source Type: research
Gynecol Oncol. 2021 Nov 26:S0090-8258(21)01605-X. doi: 10.1016/j.ygyno.2021.11.012. Online ahead of print.ABSTRACTINTRODUCTION: Ovarian cancer (OC) represent nearly 4% of gynecologic malignancies and it is often diagnosed at advanced stage. Diaphragmatic surgery, a fundamental step of advanced stage ovarian cancer (ASOC) debulking surgery, is associated with a high post-operative complication incidence, which is supposedly reduced with thoracostomy tube placement. We assessed the role of intra-operative thoracostomy tube placement, as a prevention measure for post-operative complications, after diaphragmatic resection.METH...
Source: Gynecologic Oncology - Category: Cancer & Oncology Authors: Source Type: research
Contributor : Lixin ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe aim to explore the common gene between proteomics and transcriptomics and pathway mechanism related to layer classification. Our results will provide several potential biomarkers in early diagnosis of ovarian cancer.Transcriptomics methods were performed to compare the differences between early ovarian cancer specimens (n = 3, stage Ⅰ / Ⅱ) and advanced ovarian cancer specimens (n = 6, stage Ⅲ / Ⅳ), and the similarities and differences of the data obtained were analyzed.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
g Yali Chen Ovarian cancer has the highest mortality rate in the world. Therefore, it is urgent but still challenging to develop an efficient circulating tumor cell (CTC) detection method to sensitively detect ovarian cancer. To address such issues, herein, for the first time, we present a novel CTC detection method for ovarian cancer cells by designing sensitive and rapid graphene-based biosensors. This graphene-based sensor, consisting of a cell pool and two electrodes, can be prepared by a conventional chip fabrication process. It demonstrates high-sensitivity detection even for several ovarian cancer cells by com...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
A Schneider Melissa C. Larson Matthew J. Maurer Kimberly R. Kalli Ann L. Oberg S. John Weroha Scott H. Kaufmann The poly(ADP-ribose) binding protein CHFR regulates cellular responses to mitotic stress. The deubiquitinase UBC13, which regulates CHFR levels, has been associated with better overall survival in paclitaxel-treated ovarian cancer. Despite the extensive use of taxanes in the treatment of ovarian cancer, little is known about expression of CHFR itself in this disease. In the present study, tissue microarrays containing ovarian carcinoma samples from 417 women who underwent initial surgical debulki...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
Conclusions: Non-BRCA gene mutations are frequently identified in breast cancer patients with high risk factors. Family history showed a correlation with both BRCA (p = 0.005) and non-BRCA HRR gene mutation status (p = 0.036), so we strongly suggest that breast cancer patients with a BRCA-related family history receive comprehensive gene mutation testing in China, especially HRR genes, which are not only related to high risk of breast cancer, but also potentially related to poly ADP ribose polymerase inhibitor (PARPi) targeted therapy. The exact relationship of rare gene mutations to breast cancer predisposition and the pa...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
ConclusionsThe prognosis and clinical behavior of NETs associated with ovarian teratomas are good with long progression-free survival.
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
More News: Cancer | Cancer & Oncology | Genetics | OBGYN | Ovarian Cancer | Ovaries