Drug-drug Interaction Study of Ganaplacide and Lumefantrine With Itraconazole

Condition:   Malaria Interventions:   Drug: Ganaplacide;   Combination Product: Lumefantrine;   Drug: Itraconazole Sponsors:   Novartis Pharmaceuticals;   Medicines for Malaria Venture Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

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In the rural communities of sub-Saharan African (sSA) countries, malaria is being managed using phytocompounds. Artesunate is reported to inhibit Gephyrin E, a central, multi-domain scaffolding protein of inhibitory post-synapses. Neem plant and its metabolites like azadirachtin are being indicated for management of malaria by traditional healers. The present study was aimed to cheminformatically analyse the binding potential of artesunate and azadirachtin with various reactive moieties of Gephyrin E, to reduce malaria scourge. With molecular dynamics (MD), binding free energy estimation and binding affinity of artesunate ...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Conclusions: Low platelet counts could delay suspecting and testing for malaria. Eliciting a history of travel to a malaria-endemic country could provide an important and discerning clue to suspect and test for malaria in such patients.
Source: Journal of Global Infectious Diseases - Category: Infectious Diseases Authors: Source Type: research
Control measures have significantly reduced malaria morbidity and mortality in the last two decades; however, the downward trends have stalled and have become complicated by the emergence of COVID-19. Significant efforts have been made to develop malaria vaccines, but currently only the RTS,S/AS01 vaccine against Plasmodium falciparum has been recommended by the WHO, for widespread use among children in sub-Saharan Africa. The efficacy of RTS,S/AS01 is modest, and therefore the development of more efficacious vaccines is still needed. In addition, the development of transmission-blocking vaccines (TBVs) to reduce the paras...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
Farnesyltransferase inhibitors (FTIs) are focus for the treatment of several diseases, particularly in the field of cancer therapy. Their potential, however, goes even further, as a number of studies have evaluated FTIs for the treatment of infectious diseases such as malaria, African sleeping sickness, leishmaniosis, and hepatitis D virus infection. Little is known about protein prenylation mechanisms in human pathogens. However, disruption of IspA, a gene encoding the geranyltranstransferase of Staphylococcus aureus (S. aureus) leads to reprogramming of cellular behavior as well as impaired growth and decreased resistanc...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Malaria is a highly inflammatory and oxidative disease. The production of reactive oxygen species by host phagocytes is an essential component of the host response to Plasmodium infection. Moreover, host oxidative enzymes, such as xanthine oxidase, are upregulated in malaria patients. Although increased production of reactive oxygen species contributes to the clearance of the parasite, excessive amounts of these free radicals can mediate inflammation and cause extensive damage to host cells and tissues, probably contributing to severe pathologies. Plasmodium has a variety of antioxidant enzymes that allow it to survive ami...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
Curr Res Microb Sci. 2021 May 8;2:100036. doi: 10.1016/j.crmicr.2021.100036. eCollection 2021 Dec.ABSTRACTGlobally, malaria continues to be an enormous public health burden, with concomitant parasite-induced damage to the gastrointestinal (GI) barrier resulting in bacteremia-associated morbidity and mortality in both adults and children. Infected red blood cells sequester in and can occlude the GI microvasculature, ultimately leading to disruption of the tight and adherens junctions that would normally serve as a physical barrier to translocating enteric bacteria. Mast cell (MC) activation and translocation to the GI durin...
Source: Cell Research - Category: Cytology Authors: Source Type: research
Curr Res Microb Sci. 2020 Dec 14;2:100017. doi: 10.1016/j.crmicr.2020.100017. eCollection 2021 Dec.ABSTRACT•Discuss molecular components for the coordination of circadian rhythm of malaria parasites inside the vertebrate host.•Synthetic indole compounds show antimalarial activity in vitro against P.falciparum 3D7.•Plasmodium falciparum synchronizes in cell culture upon melatonin treatment.PMID:34841309 | PMC:PMC8610328 | DOI:10.1016/j.crmicr.2020.100017
Source: Cell Research - Category: Cytology Authors: Source Type: research
Am J Trop Med Hyg. 2021 Nov 29:tpmd210747. doi: 10.4269/ajtmh.21-0747. Online ahead of print.ABSTRACTTropical alluvial gold and gem miners are often an especially at-risk population for malaria infection. Geographical areas of mining-associated malaria epidemics in the recent past include Southeast Asia (Cambodia, Thailand, and Myanmar); the Amazon basin (Brazil, French Guyana, Suriname, Columbia, and Peru); and tropical Africa. Mobile populations of young adult men engaged in the hard labor of mining may experience severe malaria especially if they lack preexisting immunity and are irregularly consuming antimalarial drugs...
Source: The American Journal of Tropical Medicine and Hygiene - Category: Tropical Medicine Authors: Source Type: research
In conclusion, findings from this study advance knowledge of the understanding of the dynamic of P. vivax population, which will contribute to guiding the rational design of a PvDBP-II based vaccine.
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
CONCLUSIONS: New signal functions have been developed which can be used for monitoring and evaluation of content and quality of ANC. Country adaptation and validation is recommended.PMID:34839568 | DOI:10.1111/1471-0528.17029
Source: BJOG : An International Journal of Obstetrics and Gynaecology - Category: OBGYN Authors: Source Type: research
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