Shigella evades pyroptosis by arginine ADP-riboxanation of caspase-11

This study reports the identification of a new post-translational modification, termed ADP riboxanation, which is mediated by the Shigella effector OspC3 and inactivates the cytosolic LPS sensing pathway of caspase-4 and caspase-11.

Source: Nature AOP - October 20, 2021 Category: Research Authors: Zilin Li Wang Liu Jiaqi Fu Sen Cheng Yue Xu Zhiqiang Wang Xiaofan Liu Xuyan Shi Yaxin Liu Xiangbing Qi Xiaoyun Liu Jingjin Ding Feng Shao Source Type: research