Prevalence of anti-platelet factor 4/polyanionic antibodies after COVID-19 vaccination with ChAdOx1 nCoV-19 and CoronaVac in Thais

CONCLUSION: We found a low prevalence of anti-PF4 antibodies in Thais after vaccination with ChAdOx1 nCoV-19 and CoronaVac. None of the antibodies were functional and lacked an association with VITT.PMID:34667921 | PMC:PMC8505225 | DOI:10.1002/rth2.12600
Source: Thrombosis and Haemostasis - Category: Hematology Authors: Source Type: research

Related Links:

Newly developed vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have shown efficacy against severe illness and death caused by coronavirus infection 2019 (COVID-19). Among the rare adverse events, there are cases of immune thrombocytopenic purpura (ITP) reported in association with COVID-19 vaccination. ITP is a condition of low platelet counts characterized by immune-mediated platelet destruction. Detection of platelet autoantibodies is often challenging, and due to the absence of clear biomarkers, diagnosis of ITP is made after excluding other causes of thrombocytopenia.
Source: Thrombosis Research - Category: Hematology Authors: Tags: Letter to the Editors-in-Chief Source Type: research
ConclusionFurther studies are needed to better identify VITT’s pathophysiological mechanisms and genetic, demographic, or clinical predisposition of high-risk patients, to investigate the correlation of VITT with the different vaccine types, and to test the significance of the findings.
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
CONCLUSION: We report a case of VITT following HPV-vaccination. This should raise awareness of the possibility of VITT also occurring after other vaccines, not exclusively adenoviral vector-based SARS-CoV2 vaccines.PMID:34817130 | DOI:10.1111/jth.15604
Source: Thrombosis and Haemostasis - Category: Hematology Authors: Source Type: research
AbstractVaccine-induced immune thrombotic thrombocytopenia (VITT) is a life-threatening complication described after administration of recombinant adenoviral vector encoding the spike protein antigen of Severe Acute Respiratory Syndrome CoronaVirus-2. The syndrome is characterized by platelet consumption and thrombosis. High levels of antibodies to platelet factor 4 (PF4) –polyanion complexes were identified in many patients with VITT by enzyme-linked immunosorbent assay (ELISA). A 64-year-old woman presented with thrombocytopenia, right renal vein thrombosis with renal infarction, right intra-right atrium and intra-...
Source: Journal of Thrombosis and Thrombolysis - Category: Hematology Source Type: research
This study aims to review the pathophysiology, diagnosis, and management of vaccine-induced thrombotic thrombocytopenia, to provide a concise and comprehensive update.PMID:34745596 | PMC:PMC8556865 | DOI:10.1016/j.amsu.2021.102988
Source: Annals of Medicine - Category: Internal Medicine Authors: Source Type: research
AbstractSince the emergence of the coronavirus disease 2019 (COVID-19) pandemic, multiple but rare complications of this infection have been described, comprising cerebral venous sinus thrombosis (CVST) and immune thrombocytopenic purpura (ITP). Although these two complications have been reported as separate entities, to the best of our knowledge, their concurrent presentation has not been reported. In this case report, we present a middle-aged man with a history of COVID-19 infection who developed a sudden-onset severe occipital headache followed by right-sided blindness (right homonymous hemianopia). Upon his diagnostic ...
Source: Neurology and Therapy - Category: Neurology Source Type: research
In conclusion, both virus-based COVID-19 vaccines show more SAEs than BNT, but the frequency of the SAE type in the different age groups differs, suggesting that the mechanisms responsible of SAEs overlap only partly.PMID:34710832 | PMC:PMC8547775 | DOI:10.1016/j.jaut.2021.102742
Source: Journal of Autoimmunity - Category: Allergy & Immunology Authors: Source Type: research
Semin Thromb Hemost DOI: 10.1055/s-0041-1736168Despite the huge efforts globally underway for preventing or limiting the spread of severe acute respiratory coronavirus disease 2 (SARS-CoV-2), the coronavirus disease 2019 (COVID-19) pandemic outbreak appears still virtually unstoppable. As for many other infectious diseases, COVID-19 vaccination has now become crucial for limiting viral spread, especially for averting hospitalizations, need for intensive care, and fatal outcome. Nonetheless, as for other vaccines, COVID-19 vaccination is not completely free from side effects. Among the adverse events that have been reported...
Source: Seminars in Thrombosis and Hemostasis - Category: Hematology Authors: Tags: Review Article Source Type: research
CONCLUSION: We found a low prevalence of anti-PF4 antibodies in Thais after vaccination with ChAdOx1 nCoV-19 and CoronaVac. None of the antibodies were functional and lacked an association with VITT.PMID:34667921 | PMC:PMC8505225 | DOI:10.1002/rth2.12600
Source: Thrombosis and Haemostasis - Category: Hematology Authors: Source Type: research
Vaccination is an effective strategy to reduce the burden of the coronavirus disease 2019 (COVID-19) pandemic. A number of vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been approved and proven highly effective, without a counterbalancing safety signal in randomized trials [1 –4].
Source: Thrombosis Research - Category: Hematology Authors: Tags: Letter to the Editors-in-Chief Source Type: research
More News: Coronavirus | COVID-19 | Health Management | Hematology | Study | Thrombocytopenia | Thrombosis | Vaccines