Transcatheter Arterial Embolization Using Imipenem/Cilastatin Sodium for Chronic Low Back Pain Resistant to Conservative Treatment: A Pilot Study with 2-Year Follow-Up

AbstractPurposeTo evaluate the safety and 2-year follow-up clinical outcomes of transcatheter arterial embolization (TAE) using imipenem/cilastatin sodium for chronic low back pain resistant to conservative treatment.Materials and MethodsA retrospective review identified 14 patients who underwent TAE for chronic low back pain between October 2017 and August 2018. Patients with low back pain related to the facet or sacroiliac joint, lasting  ≥ 6 months, refractory to ≥ 3 months of conservative treatment were eligible for TAE. Each patient received embolization of feeding arteries of painful regions. The changes in brief pain inventory (BPI) scores, adverse events, and the Oswestry Disability Index (ODI) were evaluated at baseline and 1, 3, and 24 months after TAE. Clinical success was defined as BPI maximum pain intensity decrease of ≥ 2 and ODI decrease of ≥ 10 points from baseline.ResultsFollow-up data were available in 13 and 11 patients, at 3 and 24  months after embolization, respectively. Intention-to-treat clinical success was obtained in 11/14 (79%) of patients at 3 months and 8/14 (57%) of patients at 24 months after TAE. Mean BPI maximum pain intensity and ODI scores decreased significantly from baseline to 1, 3, and 24 months after t reatment (7.6 vs.. 4.3, 3.4, and 4.1; 40.8 vs 21.5, 20.0, and 23.8, respectively; allP 
Source: CardioVascular and Interventional Radiology - Category: Radiology Source Type: research

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J Fam Pract. 2021 Oct;70(8):E2-E3. doi: 10.12788/jfp.0291.ABSTRACTYes, it is somewhat effective. Exercise therapy-including general exercise, yoga, Pilates, and motor control exercise-has been shown to modestly decrease pain in chronic low back pain (LBP); levels of benefit in short- (≤ 3 months) and long- (≥ 1 year) term follow-up range from 4% to 15% improvement (strength of recommendation [SOR] A, based on a systematic review of randomized controlled trials [RCTs]).Exercise therapy may improve function and decrease work disability in subacute and chronic LBP, respectively (SOR A, based on a meta-analysis of RCTs)....
Source: The Journal of Family Practice - Category: Practice Management Authors: Source Type: research
This study compared the effects of cognitive behavioural therapy and core stabilization exercise on pain-related disability, psychological status and sleep disturbance in patients with NSCLBP.
Source: Physiotherapy - Category: Physiotherapy Authors: Tags: P179 Source Type: research
Using data from three large samples of adults with chronic low back pain, we examined associations of the three PROMIS scores with the Oswestry Disability Index and the Roland-Morris Disability Questionnaire.
Source: RAND Research Health and Health Care - Category: Health Management Authors: Source Type: research
This study examined whether pathways within the FAM were moderated by treatment engagement in 508 people with chronic low back pain. Measures of disability, pain, fear, catastrophizing, anxiety, depression, and self-efficacy were collected through self-report, and descriptors of treatment engaged within the last month (physical activity type, medication, allied and medical health practitioner). Moderated mediation analyses were performed to examine the conditional effect of treatment engagement on fear-avoidance pathways. Results: The conditional effect of anxiety on disability was only significant for people who di...
Source: The Clinical Journal of Pain - Category: Anesthesiology Tags: Original Articles Source Type: research
CONCLUSION: Although less effective than alternate interventions, walking/running was slightly more effective than minimal/no intervention for treating chronic/recurrent LBP. J Orthop Sports Phys Ther, Epub 16 Nov 2021. doi:10.2519/jospt.2022.10612.PMID:34783263 | DOI:10.2519/jospt.2022.10612
Source: Physical Therapy - Category: Physiotherapy Authors: Source Type: research
Conclusions: Regarding prediction accuracy, BSS has been considered competitive with established machine-learning approaches. Nonetheless, considerable misclassification is inherent and further refinements are required to improve predictions.
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
This study was conducted in two phases. The first phase involved translation and cross-cultural adaptation of the PSEQ into Arabic. The second phase aimed to examine the reliability and validity of the PSEQ-A. One hundred Arab people with chronic LBP completed the PSEQ-A and some self-report questionnaires, such as pain intensity, fear of movement, disability, and life quality.RESULTS: Cronbach's alpha for the PSEQ-A was 0.90. The interclass correlation coefficient of the PSEQ-A was 0.79. The standard error of the measurement and the minimal detectable change of the PSEQ-A scores were 5.27 and 14.60, respectively. The PSEQ...
Source: Physiotherapy Theory and Practice - Category: Physiotherapy Authors: Source Type: research
CONCLUSION: cNLBP participants had altered muscle activation strategy to maintain postural stability in response to perturbation. This study further discovered that pain-related disabilities of cNLBP participants were likely related to the APAs capacity, whereas the pain intensity may relate to the CPAs capacity. Pain and disability may therefore be related to the control process of the posture-related muscles.PMID:34765050 | PMC:PMC8577937 | DOI:10.1155/2021/9054152
Source: Pain Research and Management - Category: Anesthesiology Authors: Source Type: research
In conclusion, VR can significantly reduce pain intensity and kinesiophobia in patients with chronic low back pain after the intervention and at followup. However, high heterogeneity exists and can influence the consistency of the results.
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Systematic Review Source Type: research
This study is a multisite, single-blinded, randomized controlled, parallel arm, Phase II trial conducted across 3 clinical research sites. A total of 180 people between 60 and 85 years of age with CLBP and hip pain are being recruited. Participants undergo a comprehensive baseline assessment and are randomized into 1 of 2 intervention arms: hip-focused or spine-focused. They are treated twice weekly by a licensed physical therapist for 8 weeks and undergo follow-up assessments at 8 weeks and 6 months after randomization. Primary outcome measures include the Quebec Low Back Disability Scale and the 10-Meter Walk Test, which...
Source: Physical Therapy - Category: Physiotherapy Authors: Source Type: research
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