Peptide Conjugates of 18 β-Glycyrrhetinic Acid as Potent Inhibitors of α-Glucosidase and AGEs-Induced Oxidation

In conclusion, our data demonstrates that besides possessing strong α-glucosidase inhibition, the peptide conjugates also alleviated the AGEs-induced NO• production in RAW macrophages. Dual inhibition of α-glucosidase enzyme, and AGEs-induced NO• production by 18β-GA-peptide conjugates pave the way for further research in anti-diabetic drug discovery.PMID:34666184 | DOI:10.1016/j.ejps.2021.106045

Source: European Journal of Pharmaceutical Sciences - October 19, 2021 Category: Drugs & Pharmacology Authors: Sadiq Noor Khan Farzana Shaheen Umair Aleem Sumbla Farooq Sheikh Alfred Ngenge Tamfu Sajda Ashraf Zaheer Ul-Haq Saeed Ullah Atia-Tul- Wahab M Iqbal Choudhary Humera Jahan Source Type: research