HPV self-sampling among cervical cancer screening nonattenders: a feasibility study in Estonia

ConclusionsThe study showed the feasibility and high acceptance of HPV self-sampling among long-term screening nonattenders in Estonia. As a next step, self-sampling will be piloted in organized screening program to identify optimal dissemination strategy.Key messagesHPV self-sampling in Estonia is feasible, well accepted and has the potential for improving screening uptake among hard-to-reach women.Self-sampling strategy will be further tested within cervical cancer screening program.
Source: The European Journal of Public Health - Category: General Medicine Source Type: research

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CONCLUSIONS: As proof of concept, FISH was able to detect genetic changes and chromosomal aneuploidy discriminating oral cancer from noncancerous lesions in individuals with FA. This supports its application on oral brush biopsy-based cytology.PMID:34854575 | DOI:10.1002/cre2.519
Source: Cell Research - Category: Cytology Authors: Source Type: research
Gene. 2021 Nov 29:146083. doi: 10.1016/j.gene.2021.146083. Online ahead of print.ABSTRACTNearly three hundred thousand female patients are diagnosed with ovarian cancer in the world annually, and this number shows an increasing trend. However, characteristic symptoms caused by ovarian cancer are so few that early diagnosis remains challenging, and an effective screening method has not yet been established. Here, we conducted a case-control study in Japan to analyze the association between cervicovaginal microbiome and ovarian cancer, using 16S rRNA amplicon sequencing. Analysis of DNA extracted from cervical smear samples ...
Source: Gene - Category: Genetics & Stem Cells Authors: Source Type: research
This study applied a cross sectional design by collecting data from a convenient sample of 200 women between 20 and 70 years of age in health and public centers in Jordan. Data was then analyzed using the descriptive statistical tools of SPSS, version 21. The findings revealed that 55.5% of the participants had no information about the Pap smear, and 75% did not know the risk factors. Moreover, 50% of the sample did not know where to take the test, and 50% reported a lack of encouragement from the husband to undertake the test. More than half of the participants (56.5%) expressed fear that cervical screening woul...
Source: International Journal of Human Rights in Healthcare - Category: International Medicine & Public Health Authors: Source Type: research
ConclusionThis system combines two deep learning algorithms to enable accurate detection and classification of cell clusters based on the Bethesda system, which has been difficult to achieve in the past. We will conduct further research and development of this system as a platform for augmented reality microscopes for cytological diagnosis.
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: RESEARCH ARTICLE Source Type: research
Conclusion: The diagnosis of AGC may be related to the preneoplastic/neoplastic processes. A further comprehensive histopathological examination is required in women with AGC, aged 50 years and older, postmenopausal, HPV-positivity and concomitant squamous cell abnormality Clinicians should consider ovarian pathologies when there is no pathological finding on endometrial or cervical histopathological examination.
Source: Journal of Cytology - Category: Cytology Authors: Source Type: research
This study examined 65 female Burmese refugees who were candidates for HPV vaccinations and 106 female Burmese refugees who could have received Pap smear screenings between 2010 and 2020. Of the 65 patients aged 11 –26, 49.2% initiated the HPV vaccine series and 30.8% completed the series. In patients aged 13–17, 86.4% initiated the vaccine series and 54.6% completed the series. Of the 106 patients over 18 years of age, 32.1% had a Pap smear within the last 3 years. The need to improve HPV vaccine and Pa p smear rates in refugee populations is clear. While focusing on the designated refugee exam may h...
Source: Journal of Community Health - Category: International Medicine & Public Health Source Type: research
Exp Ther Med. 2021 Dec;22(6):1481. doi: 10.3892/etm.2021.10916. Epub 2021 Oct 25.ABSTRACTHuman papillomavirus (HPV) infection is the leading cause of cervical cancer. The Papanicolaou cytology test is the usually employed type of screening for this infection; however, its sensibility is limited. Only a small percentage of women infected with high-risk HPV develop cervical cancer with an array of genetic and epigenetic modifications. Thus, it is necessary to develop rapid, reproducible and minimally invasive technologies for screening. DNA methylation has gained attention as an alternative method for molecular diagnosis and...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Authors: Source Type: research
J Family Med Prim Care. 2021 Sep;10(9):3505-3510. doi: 10.4103/jfmpc.jfmpc_39_21. Epub 2021 Sep 30.ABSTRACTCervical cancer is a leading cause of cancer-related morbidity and mortality. It usually spreads via direct invasion and lymphatics. Few cases with superficial spread to the uterine endometrium, fallopian tubes, and ovaries have been observed. The staging of these cases, as well as management, is not yet clear due to limited data. The Federation of Gynecology and Obstetrics (FIGO) staging disregards uterine spread to upstage the disease, and it also fails to provide clear guidelines regarding the superficial extension...
Source: Primary Care - Category: Primary Care Authors: Source Type: research
Prim Care. 2021 Dec;48(4):583-595. doi: 10.1016/j.pop.2021.07.008. Epub 2021 Oct 8.ABSTRACTDeclining cervical cancer rates in the United States highlights the value of prevention and early detection of premalignant cervical disease afforded by the human papillomavirus vaccine and Pap smear. The availability of in-office loop electrosurgical excision procedure affords clinicians with a cost-effective and preferred tool for the excision of high-grade lesions of the cervix with minimal risk for severe adverse outcomes. The most recent American Society for Colposcopy and Cervical Pathology guidelines recommend a risk-based app...
Source: Primary Care - Category: Primary Care Authors: Source Type: research
Laura Flaherty was diagnosed with cervical cancer after a routine smear test. She then had a hysterectomy at 29 years old.
Source: BBC News | Health | UK Edition - Category: Consumer Health News Source Type: news
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