Chronological trends of cardiovascular diseases in Southern Tunisia over a fourteen year -period
AbstractIntroductionCardiovascular diseases are the leading cause of death worldwide and in Tunisia. In fact, as a result of progressive urbanization and westernization of lifestyle the spectrum and pattern of cardiovascular diseases CVD along with their risk factors are changing. The aim of this study was to describe the epidemiological profile of CVD hospitalizations, to evaluate their chronological trends and to estimate their future projected trends.MethodsWe retrospectively collected data from the regional morbidity registry of the University Hospital of Sfax, Tunisia, between 2003 and 2016. We included patients with ischemic heart disease (IHD), heart failure (HF) and rhythm and conduction disorder (RCD). Join-point regression analysis was performed to study chronological trends of CVD (Annual Percentage Change (APC); p).ResultsThe mean age-standardized hospital incidence rate (ASHIR) was 94.8, 20.6 and 14/100000 inhabitants/year for IHD, HF and RCD, respectively. Trends analysis of CVD showed a significant increase in the ASHIR of IHD from 54.3/100000 inhabitants in 2003 to 123/100000 inhabitants in 2016, with an Annual Percentage Change (APC) of 3.59% (95% confidence interval (CI):0.4-6.7%; p
Introduction: One third of people over 65, having frequent overdiagnoses of COPD/asthma, complain of dyspnea.Aims and objectives: We investigated geriatric population, whether unrelieved dyspnea was due to inaccurate diagnoses.Methods: Subjects over 65 years of age with chronic dyspnea were evaluated. Sociodemographic data, previous diagnoses and treatment were recorded. After physical examination, subjects underwent routine tests and performed spirometric tests. Differential diagnosis of dyspnea was made.Results: 200 subjects (57F:43M) finishing all diagnostic steps were recruited into study. 70% of them had a diagnosis o...
Conclusion: Risk of CVD is higher among individuals with moderate+ COPD compared to those without COPD, although this increase may go undetected by widely used clinical cardiovascular risk scores.
Conclusions: About half of our population complains of sleep disorders, with similar occurrence in males and females. Chronic heart failure, a condition often associated with sleep respiratory disorders, has the same prevalence in the different groups.
Conclusions: COPD patients enrolled in the GULP study showed high prevalence of cardio-vascular diseases. Chronic heart failure and ischemic heart disease appeared to predict mortality in this cohort.
Conclusions: WD is a rare cause of severe but potentially reversible PH. Due to poor awareness, delayed diagnosis may lead to death due to end-stage right heart failure.
Conclusions: Taken together, these results provide evidence for the functional importance of variants in non-European populations, and suggest new biological mechanisms for ancestry-specific determinants of lipids, coagulation and myocardial function.PMID:34814699 | DOI:10.1161/CIRCULATIONAHA.121.055117
ConclusionsDiagnostic coding of HF in primary care health records is inaccurate with a high degree of under-registration and over-registration. An optimized query set enabled identification of more than 80% of GPs' self-assessed HF population.
We report the first case of untreated patient with myeloma who had been successfully treated with daratumumab, lenalidomide, and dexamethasone therapy even in dialysis requiring state. Daratumumab may benefit patients with acute kidney injury caused by multiple myeloma, owing to the immediate need of FLC level reduction. Daratumumab and lenalidomide combination therapy could be a valuable treatment option for patients requiring dialysis when bortezomib may be hesitate to use due to severe heart disease.
Conclusion: TCMIs combined with CT are better than CT alone in treating CHD-HF. Different TCMIs improve different outcomes. Additional properly designed RCTs are needed to conduce a more refined comparison of various TCMIs.Systematic Review Registration: [https://www.crd.york.ac.uk/PROSPERO/], identifier [CRD42021258263].
Pflugers Arch. 2021 Nov 22. doi: 10.1007/s00424-021-02638-8. Online ahead of print.ABSTRACTInsulin resistance plays a key role in the development and progression of obesity, diabetes, and their complications. Moreover, insulin resistance is considered the principal link between metabolic diseases and cardiovascular diseases. Heart disease associated with insulin resistance is one of the most important consequences of both obesity and diabetes, and it is characterized by impaired cardiac energetics, diastolic dysfunction, and finally heart failure. Mitochondrion plays a key role in cell energy homeostasis and is the main so...