Hodgkin lymphoma with diplopia and nystagmus: a paraneoplastic cerebellar degeneration with ectopic expression of DNER antigen on Reed-Sternberg cells
Paraneoplastic neurological syndromes (PNSs) are heterogeneous and rare disorders (less than 1% of all neoplastic conditions) associated with various type of neoplasms, including both non-Hodgkin's lymphomas (NHLs) and Hodgkin's lymphoma (HL).1 –3 The primary cause is recognized in the aberrant immunological response against nervous tissue usually triggered by ectopic expression of so-called onco-neural antigens on neoplastic cells.2,4,5 This mechanism can be highlighted by the occurrence of onconeural antibodies which represent a powerf ul diagnostic tool, according to Graus and colleagues’ criteria.
Source: Clinical Lymphoma, Myeloma and Leukemia - Category: Hematology Authors: Nicolas Fiorelli, Sara Fraticelli, Arturo Bonometti, Luca Diamanti, Matteo Paoletti, Diego Franciotta, Manuel Gotti, Marco Lucioni, Marco Paulli, Luca Arcaini Tags: Case Report Source Type: research
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