Novel Non-Invasive Radiomic Signature on CT Scans Predicts Response to Platinum-Based Chemotherapy and Is Prognostic of Overall Survival in Small Cell Lung Cancer

ConclusionsRadiomic features extracted within and around the lung tumor on CT images were both prognostic of OS and predictive of response to chemotherapy in SCLC patients.
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research

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CONCLUSIONS: Radiomic features extracted within and around the lung tumor on CT images were both prognostic of OS and predictive of response to chemotherapy in SCLC patients.PMID:34745966 | PMC:PMC8564480 | DOI:10.3389/fonc.2021.744724
Source: Clinical Lung Cancer - Category: Cancer & Oncology Authors: Source Type: research
We report a rare case of triple metachronous lung cancer and review of literature of patients with triple metachronous cancers. This will be the second case reported of triple metachronous lung cancer. Patient concerns: A 60-year-old male, active smoker with diabetes mellitus, chronic obstructive pulmonary disease (COPD) and peripheral arterial disease presented with cough and hemoptysis. Initial computed tomography (CT) scan showed right upper lobe spiculated mass. Diagnosis: He underwent transthoracic needle biopsy for right upper lobe mass, showing primary lung adenocarcinoma (ADC)-Stage-IIIA. He continued...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
Conclusion: In ED-SCLC patients, C-TRT may prevent isolated local recurrence and may improve 1-year survival. This survival improvement might be the reflection of high intrathoracic control achieved in 77% of patients.
Source: Journal of Cancer Research and Therapeutics - Category: Cancer & Oncology Authors: Source Type: research
Conclusions: As previously reported, we confirmed that the greater the degree of neutropenia, the better the treatment response. However, the effect of patient’s BMI, TG, LDL, and HDL on neutropenia was not statistically significant. Since predicting the degree of neutropenia is important, we will continue our efforts to find relevant factors.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Lung cancer Source Type: research
ConclusionsQuantifying CT density change within irradiated lung parenchyma may offer a novel approach to predict radiation associated pulmonary toxicities. Measuring density changes across patient cohorts receiving TRT with novel systemic therapies may help to identify combined treatment strategies likely to be associated with diminished risk of toxicity.Legal entity responsible for the studyThe authors.FundingBristol-Myers Squibb.DisclosureS. Kim: Research grant / Funding (institution): Bristol-Myers Squibb. S.A. Rosenberg: Advisory / Consultancy: Novocure. J.E. Gray: Honoraria (self), Advisory / Consultancy, Research gra...
Source: Annals of Oncology - Category: Cancer & Oncology Source Type: research
ConclusionsMTV and glu-SUVmax measured on pretreatment18F-FDG PET/CT were independent prognostic factors for LD-SCLC patients after chemoradiotherapy with curative intent. These metabolic markers need validation in larger prospective studies but may be useful in the clinical care of LD-SCLC patients.
Source: Journal of Cancer Research and Clinical Oncology - Category: Cancer & Oncology Source Type: research
Conclusion: Significantly more patients had unilateral rather than bilateral regional differences (both increases and decreases) in 18F-FDG uptake in the brain pre-and post PCI. This suggests that differences in unilateral distribution are related to functional changes, since direct toxicity alone from PCI and chemotherapy would be symmetric. The frontal region was the most commonly affected, suggesting a potential contributing etiology for cognitive impairment and decreased executive function after therapy. PMID: 30076247 [PubMed - as supplied by publisher]
Source: Journal of Nuclear Medicine Technology - Category: Nuclear Medicine Tags: J Nucl Med Technol Source Type: research
283Objectives: Small cell lung cancer (SCLC), which accounted for about 15-20% of lung cancers and is a rapidly disseminating cancer with poor prognosis. Concurrent chemo-radiation is currently the first choice treatment. However, disease control remains heterogeneous. Therefore, the ability to predict the benefit from treatment would be of great clinical value. The aim of the current study was to evaluate the prognostic value of "early" and "late" metabolic response in patients with small cell lung cancer with chemoradiation by 18F-FDG PET/CT. Methods Baseline and repeat 18F-FDG PET/CT scans were perfo...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Lung Cancer II: PET-Derived Parameters as Predictors of Response to Therapy Source Type: research
Rationale: Only few cases of myasthenia gravis (MG) associated with small-cell lung cancer (SCLC) have been reported, and cases positive for acetylcholine receptor antibody (AChR-ab) are even rarer. The efficacy of standard MG treatment, such as cholinesterase inhibitor therapy, immunosuppressive therapy using steroids and immunosuppressive drugs, plasma exchange, and intravenous immune globulin (IVIg), for these cases is unclear. Patient concerns and diagnoses: A 71-year-old man complained of bilateral eyelid ptosis. He also presented with dysphagia and masticatory muscle fatigue after chewing. The edrophonium test w...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
Conclusions: The ovary is a common site of metastases from GI, breast, liver, pancreas, kidney cancers, but very rarely from a primary lung (0.3-4%). Immunotherapy could be an useful therapeutic option for treatment expecially in young patients.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Lung Cancer Source Type: research
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