Construction of an Immune Cell Infiltration Score to Evaluate the Prognosis and Therapeutic Efficacy of Ovarian Cancer Patients

ConclusionICI score is an effective prognosis-related biomarker for OC and can provide valuable information on the potential response to immunotherapy.
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research

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‚oska Ovarian cancer is one of the most fatal cancers in women worldwide. Cytoreductive surgery combined with platinum-based chemotherapy has been the current first-line treatment standard. Nevertheless, ovarian cancer appears to have a high recurrence rate and mortality. Immunological processes play a significant role in tumorigenesis. The production of ligands for checkpoint receptors can be a very effective, and undesirable, immunosuppressive mechanism for cancers. The CTLA-4 protein, as well as the PD-1 receptor and its PD-L1 ligand, are among the better-known components of the control points. The aim of this paper...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
Conclusion: The implementation of immunotherapy in the primary treatment schedule of ovarian cancer cannot be induced blindly. Carboplatin–paclitaxel seems to ameliorate the hostile immune microenvironment in ovarian cancer, which is less pronounced at the end of primary treatment. This prospective study during primary therapy for ovarian cancer that also looks at the evolution of immune-related proteins provides us with an insight into the temporary windows of opportunity in which to introduce immunotherapy during primary treatment.
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
Ovarian cancer (OC) is a devastating malignancy with a poor prognosis. The complex tumor immune microenvironment results in only a small number of patients benefiting from immunotherapy. To explore the different factors that lead to immune invasion and determine prognosis and response to immune checkpoint inhibitors (ICIs), we established a prognostic risk scoring model (PRSM) with differential expression of immune-related genes (IRGs) to identify key prognostic IRGs. Patients were divided into high-risk and low-risk groups according to their immune and stromal scores. We used a bioinformatics method to identify four key I...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
CONCLUSION: It was the first study to identify a novel signature developed by DEirPseus pairs and verify the role in predicting OS, immune infiltrates, immunotherapy, and chemosensitivity. The irPseus are vital factors predicting the prognosis of OC and could act as a novel potential treatment target.PMID:34659427 | PMC:PMC8519701 | DOI:10.1155/2021/1586312
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Authors: Source Type: research
Conditions:   Ovarian Cancer;   Neoplasm, Ovarian;   Ovarian Neoplasm;   Ovary Neoplasms;   Neoplasm, Ovary;   Neoplasms, Ovary;   Ovary Neoplasm;   Neoplasms, Ovarian;   Ovary Cancer;   Cancer, Ovarian Stromal;   Cancers, Ovary;   Ovary Cancers;   Cancer, Ovarian;   Cancers, Ovari an;   Ovarian Cancers;   Cancer of Ovary;   Cancer of the Ovary Interventions:   Drug: chemotherapy, targeted therapeutics, immunotherapy;   Radiat...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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