Substance P serum degradation in Complex Regional Pain Syndrome – another piece of the puzzle?

In a previous study, we demonstrated that the serum peptidase system might be less efficient in complex regional pain syndrome (CRPS). Since the neuropeptide substanc P (SP) contributes to inflammation in CRPS, we now investigated the metabolism of SP in CRPS specifically. An SP metabolism assay was performed in 24 CRPS patients, which constitute a subgroup of our previous investigation on BK degradation. In addition, we included 26 healthy controls (24 newly recruited plus 2 from our previous investigation), and 13 patients after limb trauma, who did not fulfil the CRPS diagnostic criteria (trauma controls, TC) were included.

Source: The Journal of Pain - October 19, 2021 Category: Materials Science Authors: Simone K önig, Christian Engl, Malte Bayer, Fabiola Escolano-Lozano, Heike Rittner, Cora Rebhorn, Frank Birklein Source Type: research