Timing of adjuvant chemotherapy after laparotomy for Wilms tumor and neuroblastoma

ConclusionThere is no association between early initiation of adjuvant chemotherapy and post-operative complications including wound healing. Early initiation of chemotherapy ( ≤ 7 days) is feasible in unilateral WT or high-risk neuroblastoma patients who are otherwise doing well without resulting in a preponderance of wound healing complications.
Source: Pediatric Surgery International - Category: Surgery Source Type: research

Related Links:

People with Down syndrome have unique characteristics as a result of the presence of an extra chromosome 21. Regarding cancer, they present a unique pattern of tumors, which has not been fully explained to date. Globally, people with Down syndrome have a similar lifetime risk of developing cancer compared to the general population. However, they have a very increased risk of developing certain tumors (e.g., acute leukemia, germ cell tumors, testicular tumors and retinoblastoma) and, on the contrary, there are some other tumors which appear only exceptionally in this syndrome (e.g., breast cancer, prostate cancer, medullobl...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
CONCLUSIONS: Robotic surgery for pediatric tumors is a safe option in highly selected cases. Indications should be discussed by tumor boards to avoid widespread and uncontrolled application.PMID:34523002 | DOI:10.1245/s10434-021-10777-6
Source: Ann Oncol - Category: Cancer & Oncology Authors: Source Type: research
AbstractBackgroundThere is a well-recognized male excess in childhood cancer incidence; however, it is unclear whether there is etiologic heterogeneity by sex when defined by epidemiologic risk factors.MethodsUsing a 5-state registry-linkage study (casesn = 16,411; controlsn = 69,816), we estimated sex-stratified odds ratios (OR) and 95% confidence intervals (95% CI) between birth and demographic characteristics for 16 pediatric cancers. Evidence of statistical interaction (p-interaction   50% of cases for all cancers, except Wilms tumor (49.6%). Sex interacted with a number of ris...
Source: Cancer Causes and Control - Category: Cancer & Oncology Source Type: research
Inflammation is of great importance for malignancy and a persistent inflammatory response can drive tumor growth [1, 2]. Childhood cancer is the second most common cause of death among children in high-income countries and the most prevalent diagnoses are leukemia, lymphoma, neuroblastoma, Wilms tumor, rhabdomyosarcoma, bone and brain tumors. In the latest decades survival has dramatically improved using a multimodal approach including chemotherapy, radiation and surgery, but recently the survival seems to have reached a plateau.
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - Category: Biomedical Science Authors: Source Type: research
Invasive fungal infections (IFIs) are an important cause of morbidity and mortality in children with cancer. Studies on the clinical characteristics of IFI in children with solid tumors are limited. This Dutch retrospective cohort study reviewed the medical records of 61 children with solid tumors to analyze the clinical characteristics during their full treatment period. Seven IFI episodes were reported in 6/61 patients (10%), all diagnosed with intermediate-risk or high-risk Wilms tumor or neuroblastoma. Larger studies are necessary to reveal the determinants of IFI in this group of patients and the value of fungal prophylaxis.
Source: Journal of Pediatric Hematology Oncology - Category: Hematology Tags: Online Articles: Clinical and Laboratory Observations Source Type: research
Gütgemann Pediatric tumors frequently arise from embryonal cells, often displaying a stem cell-like (“small round blue”) morphology in tissue sections. Because recently “stemness” has been associated with a poor immune response in tumors, we investigated the association of prognostic gene expression, stemness and the immune microenvironment systematically using transcriptomes of 4068 tumors occurring mostly at the pediatric and young adult age. While the prognostic landscape of gene expression (PRECOG) and infiltrating immune cell types (CIBERSORT) is similar to that of tumor entities occur...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
Progresses over the past years have extensively improved our capacity to use genome-scale analyses—including high-density genotyping and exome and genome sequencing—to identify the genetic basis of pediatric tumors. In particular, exome sequencing has contributed to the evidence that about 10% of children and adolescents with tumors have germline genetic variants associated with cancer predisposition. In this review, we provide an overview of genetic variations predisposing to solid pediatric tumors (medulloblastoma, ependymoma, astrocytoma, neuroblastoma, retinoblastoma, Wilms tumor, osteosarcoma, rhabdomyosar...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
ConclusionsAt present, there is insufficient evidence to evaluate the effects of routine surveillance imaging on survival in most pediatric extracranial solid tumors. More high ‐quality data are required, preferably through randomized controlled trials with well‐conducted qualitative elements.
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research
Publication date: April 2020Source: Cancer Epidemiology, Volume 65Author(s): Julie Volk, Julia E. Heck, Kjeld Schmiegelow, Johnni HansenAbstractBackgroundParental occupational exposures are suggested as contributing causes of childhood cancer.MethodsChildren age
Source: Cancer Epidemiology - Category: Cancer & Oncology Source Type: research
AbstractPediatric solid tumors have long been known to shed tumor cells, DNA, RNA, and proteins into the blood. Recent technological advances have allowed for improved capture and analysis of these typically scant circulating materials. Efforts are ongoing to develop “liquid biopsy” assays as minimally invasive tools to address diagnostic, prognostic, and disease monitoring needs in childhood cancer care. Applying these highly sensitive technologies to serial liquid biopsies is expected to advance understanding of tumor biology, heterogeneity, and evolution over the course of therapy, thus opening new avenues f...
Source: Cancer and Metastasis Reviews - Category: Cancer & Oncology Source Type: research
More News: Brain | Cancer | Cancer & Oncology | Chemotherapy | Children | Laparotomy | Neuroblastoma | Neurology | Neurosurgery | Pediatrics | Study | Surgery | Wilm's Tumor