Lung transplantation for post ‐COVID‐19 pulmonary fibrosis

We present a case of an otherwise healthy 34-year-old male who developed end-stage pulmonary fibrosis following COVID-19 infection. He achieved haemodynamic stability with mechanical ventilation and extracorporeal membrane oxygenation (ECMO) but did not show any sign of weaning off ECMO; however, he successfully underwent bilateral lung transplantation.
Source: Respirology Case Reports - Category: Respiratory Medicine Authors: Tags: CASE REPORT Source Type: research

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In this study, they found these drugs can kill senescent cells from cultures of human fat tissue. The tissue was donated by individuals with obesity who were known to have metabolic troubles. Without treatment, the human fat tissues induced metabolic problems in immune-deficient mice. After treatment with dasatinib and quercetin, the harmful effects of the fat tissue were almost eliminated. Targeting p21Cip1 highly expressing cells in adipose tissue alleviates insulin resistance in obesity Insulin resistance is a pathological state often associated with obesity, representing a major risk factor for type 2...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
When it comes to receiving organ transplants, patients are not usually judged on prior behavior, but some doctors are questioning whether unvaccinated COVID patients should qualify for new lungs.(Image credit: Vezna Hang )
Source: NPR Health and Science - Category: Consumer Health News Authors: Source Type: news
This study describes the case of an 18-years-old male affected by severe COVID-19, who was receiving bilateral lung transplantation (LT), after 71 days of mechanical ventilation and 55 days of veno-venous extracorporeal membrane oxygenation. From post-operative day 2, early mobilization and physiotherapy treatments were performed. Weaning from mechanical ventilation, the use of non-invasive ventilation and tracheostomy management were included in the treatment. Forty-five days after LT the patient was discharged at home, showing improvements in terms of functional and respiratory parameters, quality of life and mood. While...
Source: Monaldi Archives for Chest Disease - Category: Respiratory Medicine Authors: Source Type: research
Conclusion: According to our study, COVID-19 infection in children with chronic lung disease has a mild course similar to that in children without chronic diseases.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Paediatric respiratory infection and immun. Source Type: research
Conclusion: Tele-coaching appears feasible in lung transplant recipients, with patients wearing the pedometer and interacting well with the app over 12 weeks. This is promising in the current climate, with the need to develop and evaluate novel ways of supporting patients remotely.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: m-Health/e-health Source Type: research
Conclusion: LT is feasible for COVID-19 induced ARDS and should be considered for carefully selected patients with irreversible lung injury.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Transplantation Source Type: research
Conclusions: We found a higher mortality and more severe disease course in LTX than in the healthy population. Recurrence of COVID-19 is a frequent event. At mid-term, we did not observe significant new incidence of CLAD onset. Treatment of COVID-19 and risk of CLAD after COVID-19 in LTX require further studies.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Transplantation Source Type: research
COVID 19 (SARS-COV-2) disease expression remains uncertain. Immunocompromised individuals may be at particular risk of increased mortality. Lung transplant recipients provide a unique phenotype because the allograft is a preferred host location for the SARS-COV-2.We conducted a single centre review of all lung transplant recipients SARS-COV-2 PCR positive between 17th March and June 2020. 7 of a total of 266 lung transplant recipients were SARS-COV-2 positive. 4 cases had a descriptive analysis of the immune microenvironment.There was no association between COVID 19 disease severity and time from transplant. The most preva...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Transplantation Source Type: research
Conclusions: Preliminary findings show no functional differences between in-person and tele-rehab.  Pre-LTx QT was associated with post-LTx measures of lower extremity function. There was no change from pre- to post-LTx QT, however QT measured at the start of pre-habilitation may have changed during the wait for LTx.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Physiotherapists Source Type: research
More News: COVID-19 | Lung Transplant | Respiratory Medicine | Study | Transplants